Maternally sequestered therapeutic polypeptides - a new approach for the management of preeclampsia.
Maternally sequestered therapeutic polypeptides - a new approach for the management of preeclampsia.
复制标题
DOI：
10.3389/fphar.2014.00201
复制
发表时间：
2014
影响因子：
5.6
通讯作者：
George EM
中科院分区：
文献类型：
--
作者：
Bidwell GL 3rd;George EM
The last several decades have seen intensive research into the molecular mechanisms underlying the symptoms of preeclampsia. While the underlying cause of preeclampsia is believed to be defective placental development and resulting placental ischemia, it is only recently that the links between the ischemic placenta and maternal symptomatic manifestation have been elucidated. Several different pathways have been implicated in the development of the disorder; most notably production of the anti-angiogenic protein sFlt-1, induction of auto-immunity and inflammation, and production of reactive oxygen species. While the molecular mechanisms are becoming clearer, translating that knowledge into effective therapeutics has proven elusive. Here we describe a number of peptide based therapies we have developed to target theses pathways, and which are currently being tested in preclinical models. These therapeutics are based on a synthetic polymeric carrier elastin-like polypeptide (ELP), which can be synthesized in various sequences and sizes to stabilize the therapeutic peptide and avoid crossing the placental interface. This prevents fetal exposure and potential developmental effects. The therapeutics designed will target known pathogenic pathways, and the ELP carrier could prove to be a versatile delivery system for administration of a variety of therapeutics during pregnancy.
登录
查看更多内容
影响因子：
3.7
作者：
Bidwell GL 3rd;Perkins E;Hughes J;Khan M;James JR;Raucher D
通讯作者：
Raucher D
影响因子：
8
作者：
Cifuentes-Pagano, Eugenia;Csanyi, Gabor;Pagano, Patrick J.
通讯作者：
Pagano, Patrick J.
核因子-kappa B、p38 和应激激活蛋白激酶丝裂原激活蛋白激酶信号通路调节人胎盘外植体中的促炎细胞因子和细胞凋亡，以响应氧化应激：抗氧化维生素的作用。
影响因子：
6
作者：
Cindrova-Davies, Tereza;Spasic-Boskovic, Olivera;Jauniaux, Eric;Charnock-Jones, D. Stephen;Burton, Graham J.
通讯作者：
Burton, Graham J.
DOI：
10.1073/pnas.92.17.7657
发表时间：
1995-08-15
影响因子：
11.1
作者：
DRAKE, CJ;LITTLE, CD
通讯作者：
LITTLE, CD
影响因子：
10.3
作者：
Dreher, MR;Liu, WG;Chilkoti, A
通讯作者：
Chilkoti, A