A 1H magnetic resonance spectroscopy study of aging in parietal white matter:: implications for trials in multiple sclerosis
A 1H magnetic resonance spectroscopy study of aging in parietal white matter:: implications for trials in multiple sclerosis
复制标题
DOI：
10.1016/s0730-725x(00)00131-4
复制
发表时间：
2000-05-01
影响因子：
2.5
通讯作者：
Thompson, AJ
中科院分区：
文献类型：
--
作者：
Leary, SM;Brex, PA;Thompson, AJ
H-1磁共振波谱(MRS)为检测和量化大脑代谢物提供了独特的工具。在多发性硬化症中，可以通过测量神经元标志物N-乙酰天冬氨酸(NAA)来研究轴突丢失或功能障碍。以前的成人研究已经报道了衰老对代谢物浓度的不同影响，但主要集中在老年人的变化上。这项研究调查了一个更年轻的成年年龄组，以提供一个更适用于多发性硬化症人群的参考数据库。对44例22~62岁的受试者进行了单体素H-1MRS检查。16名受试者在一年后进行了复查。测定NA(NAA和N-乙酰天冬氨酸之和)、NAA、肌酸/磷酸肌酸(Cr)、胆碱类化合物(Cho)和肌醇(Mi)的绝对浓度。NA、NAA和mI浓度与年龄无关，但与Cr(r=0.43，p=0.004)和Cho(r=0.38，p=0.011)浓度呈显著正相关。在一年的时间里，代谢物浓度没有显著差异。这项研究提供的证据表明，即使在年轻到中年的成年人中，代谢物浓度的年龄相关变化也会发生。这强调了在多发性硬化症的H-1MRS研究中对代谢物浓度而不是比率进行绝对量化的必要性以及年龄匹配的重要性。(C)2000 Elsevier Science Inc.保留所有权利。
H-1 magnetic resonance spectroscopy (MRS) provides a unique tool to detect and quantify brain metabolites. In multiple sclerosis it can be used to investigate axonal loss or dysfunction through measurement of N-acetyl aspartate (NAA), a neuronal marker. Previous studies in adults have reported variable effects of aging on metabolite concentrations but have predominantly focused on changes in the elderly. This study has examined a younger adult age group to provide a reference database more applicable to the multiple sclerosis population. Single voxel H-1 MRS was carried out in 44 subjects between 22 and 62 years of age. Sixteen subjects underwent repeat examination after one year. Absolute concentrations of NA (the sum of NAA and N-acetyl aspartate glutamate), NAA, creatine/phosphocreatine (Cr), choline containing compounds (Cho) and myo-inositol (mI) were measured. NA, NAA and mI concentrations did not correlate with age but there were significant correlations between age and Cr (r = 0.43, p = 0.004) and Cho (r = 0.38, p = 0.011) concentrations. No significant differences in metabolite concentrations were seen over one year. This study provides evidence that age-related changes of metabolite concentrations occur even in a young to middle aged adult population. This emphasizes the need to perform absolute quantification of metabolite concentrations rather than ratios and the importance of age-matching in H-1 MRS studies of multiple sclerosis. (C) 2000 Elsevier Science Inc. All rights reserved.