Resveratrol improves hepatic ischemia-reperfusion injury by inhibiting neutrophils via the ERK signaling pathway.
Resveratrol improves hepatic ischemia-reperfusion injury by inhibiting neutrophils via the ERK signaling pathway.
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DOI：
10.1016/j.biopha.2023.114358
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发表时间：
2023-02
期刊：
影响因子：
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通讯作者：
Yaning Wang;Xiaojing Sun;Xiaotong Han-;Jie Sun;Li Li-Li;D. Zhang;Guangyong Sun
中科院分区：
文献类型：
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作者：
Yaning Wang;Xiaojing Sun;Xiaotong Han-;Jie Sun;Li Li-Li;D. Zhang;Guangyong Sun
Hepatic ischemia-reperfusion injury (HIRI) is the main complication and even mortality in the setting of hepatic surgery or transplantation. Inflammation, especially the neutrophil response, plays important roles during the process of HIRI. In this study, we found that resveratrol preintervention ameliorated IRI-induced hepatic injury and neutrophil inflammatory responses in the liver. Moreover, RNA-sequencing analysis showed that resveratrol inhibited the functions of neutrophils, such as survival, cell cycle, migration and chemotaxis, oxidative stress and secretion of proinflammatory cytokines. Resveratrol restrained oxidative stress and the inflammatory response of neutrophils via inhibition of endothelin 1 autocrine signaling by suppressing the ERK signaling pathway. These data provide more evidence for the immunomodulatory role of resveratrol and enrich our understanding of immune strategies to improve HIRI.
