AURKB: a promising biomarker in clear cell renal cell carcinoma
AURKB: a promising biomarker in clear cell renal cell carcinoma
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作者：
Wan, Bangbei;Huang, Yuan;Lv, Cai
背景极光激酶B（A URKB）是多种肿瘤的重要致癌因子，但其在肾透明细胞癌（ccRCC）中的作用尚不清楚。本研究旨在探讨其在ccRCC中的预后价值和作用机制。ccRCC患者的基因表达谱和临床数据从癌症基因组图谱数据库下载。R软件分析A URKB在ccRCC中的表达及预后作用。采用基因集富集分析（GSEA）方法分析AURKB在ccRCC中的相关信号通路。AURKB在ccRCC组织中的表达水平高于正常肾组织。在ccRCC中增加的A URKB表达与高组织学分级、病理分期、T分期、N分期和远处转移（M分期）相关。Kaplan-Meier生存分析提示AURKB高表达患者的预后比AURKB低表达患者差。多因素考克斯分析显示AURKB表达是影响ccRCC预后的因素。GSEA表明，基因参与自身免疫性甲状腺疾病，肠道免疫网络的伊加生产，抗原加工和呈递，精氨酸-细胞因子受体相互作用，哮喘等，在AURKB高表达表型中差异富集。AURKB是预测ccRCC患者预后的有前景的生物标志物和潜在的治疗靶点。此外，AURKB可能通过调节肠道免疫网络中伊加的产生和细胞因子受体相互作用等信号通路来调节ccRCC的进展。然而，需要更多的研究来验证这些发现。
Background. Aurora kinase B (A URKB) is an important carcinogenic factor in various tumors, while its role in clear cell renal cell carcinoma (ccRCC) still remains unclear. This study aimed to investigate its prognostic value and mechanism of action in ccRCC.Methods. Gene expression profiles and clinical data of ccRCC patients were downloaded from The Cancer Genome Atlas database. R software was utilized to analyze the expression and prognostic role of A URKB in ccRCC. Gene set enrichment analysis (GSEA) was used to analyze AURKB related signaling pathways in ccRCC.Results. AURKB was expressed at higher levels in ccRCC tissues than normal kidney tissues. Increased A URKB expression in ccRCC correlated with high histological grade, pathological stage, T stage, N stage and distant metastasis (M stage). Kaplan-Meier survival analysis suggested that high A URKB expression patients had a worse prognosis than patients with low AURKB expression levels. Multivariate Cox analysis showed that AURKB expression is a prognostic factor of ccRCC. GSEA indicated that genes involved in autoimmune thyroid disease, intestinal immune network for IgA production, antigen processing and presentation, cytokine-cytokine receptor interaction, asthma, etc., were differentially enriched in the AURKB high expression phenotype.Conclusions. AURKB is a promising biomarker for predicting prognosis of ccRCC patients and a potential therapeutic target. In addition, AURKB might regulate progression of ccRCC through modulating intestinal immune network for IgA production and cytokine-cytokine receptor interaction, etc. signaling pathways. However, more research is necessary to validate the findings.