Post-yield nanomechanics of human cortical bone in compression using synchrotron X-ray scattering techniques.
Post-yield nanomechanics of human cortical bone in compression using synchrotron X-ray scattering techniques.
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DOI：
10.1016/j.jbiomech.2010.11.003
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发表时间：
2011-02-24
影响因子：
2.4
通讯作者：
Wang, Xiaodu
中科院分区：
文献类型：
--
作者：
Dong, X. Neil;Almer, Jon D.;Wang, Xiaodu
超微结构对外加载荷的反应决定了骨的屈服后变形和破坏行为，并与骨脆性骨折相关。结合一种新的渐进加载方案和同步加速器X射线散射技术，这项研究调查了局部变形的相关性（即，矿物相和胶原相的内部应变）与骨的整体机械行为。结果表明，纵向胶原纤维和矿物晶体的内部应变在屈服前与宏观应变几乎呈线性增加，屈服后先显著下降，然后逐渐趋于平稳。在骨屈服前后，所施加的应力也观察到类似的变化。然而，胶原与矿物质的应变比在整个加载过程中几乎保持恒定。此外，纵向矿物和胶原相的内部应变并没有表现出与大块骨组织的模量损失或塑性变形的线性关系。最后，在矿物相的局部变形的时间依赖性响应后，屈服观察。根据结果，我们推测，矿物晶体和胶原纤维与负载轴对齐，只能部分解释屈服后变形，这表明剪切变形涉及倾斜取向的晶体和原纤维（轴外）是人类皮质骨压缩屈服的主要机制。
The ultrastructural response to applied loads governs the post-yield deformation and failure behavior of bone, and is correlated with bone fragility fractures. Combining a novel progressive loading protocol and synchrotron X-ray scattering techniques, this study investigated the correlation of the local deformation (i.e., internal strains of the mineral and collagen phases) with the bulk mechanical behavior of bone. The results indicated that the internal strains of the longitudinally oriented collagen fibrils and mineral crystals increased almost linearly with respect to the macroscopic strain prior to yielding, but markedly decreased first and then gradually leveled off after yielding. Similar changes were also observed in the applied stress before and after yielding of bone. However, the collagen to mineral strain ratio remained nearly constant throughout the loading process. In addition, the internal strains of longitudinal mineral and collagen phases did not exhibit a linear relationship with either the modulus loss or the plastic deformation of bulk bone tissue. Finally, the time-dependent response of local deformation in the mineral phase was observed after yielding. Based on the results, we speculate that the mineral crystals and collagen fibrils aligned with the loading axis only partially explain the post-yield deformation suggesting that shear deformation involving obliquely oriented crystals and fibrils (off axis) is dominant mechanism of yielding for human cortical bone in compression.
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影响因子：
4.9
作者：
Nyman, Jeffry S.;Roy, Anuradha;Wang, Xiaodu
通讯作者：
Wang, Xiaodu
影响因子：
2.4
作者：
Hofmann, Tobias;Heyroth, Frank;Raum, Kay
通讯作者：
Raum, Kay
影响因子：
3
作者：
Almer, JD;Stock, SR
通讯作者：
Stock, SR
当受到渐进载荷时，皮质骨在压缩和拉伸之间的机械行为存在差异。
DOI：
10.1016/j.jmbbm.2008.11.008
发表时间：
2009-12
影响因子：
3.9
作者：
Nyman, Jeffry S.;Leng, Huijie;Dong, X. Neil;Wang, Xiaodu
通讯作者：
Wang, Xiaodu
影响因子：
2.4
作者：
Leng, Huijie;Dong, X. Neil;Wang, Xiaodu
通讯作者：
Wang, Xiaodu