Gold(I)-Catalyzed Angle Strain Controlled Strategy to Furopyran Derivatives from Propargyl Vinyl Ethers: Insight into the Regioselectivity of Cycloisomerization
Gold(I)-Catalyzed Angle Strain Controlled Strategy to Furopyran Derivatives from Propargyl Vinyl Ethers: Insight into the Regioselectivity of Cycloisomerization
复制标题
金 (I) 催化角应变控制策略从炔丙基乙烯基醚生成呋喃吡喃衍生物：深入了解环异构化的区域选择性。
DOI：
10.1021/acs.orglett.5b03641
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发表时间：
2016-02-19
期刊：
影响因子：
5.2
通讯作者：
Cheng, Maosheng
中科院分区：
文献类型：
--
作者：
Jin, Shengfei;Jiang, Chongguo;Cheng, Maosheng
通过金(I)催化丙炔- clisen重排/丙炔乙烯醚的6-内三环化，开发了一种独特的区域特异性合成双环呋喃衍生物的策略。在底物中引入角应变显著改变了反应的区域选择性。通过密度泛函理论计算，深入了解了环异构化的区域选择性。
A unique strategy for the regiospecific synthesis of bicyclic furopyran derivatives has been developed via a gold(I)-catalyzed propargyl-Claisen rearrangement/6-endo-trig cyclization of propargyl vinyl ethers. The introduction of angle strain into the substrates significantly altered the reaction's regioselectivity. Insight into the regioselectivity of the cycloisomerization was obtained with density functional theory calculations.