Microfluidic large-scale integration

Microfluidic large-scale integration
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DOI:
10.1126/science.1076996
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发表时间:
2002-10-18
期刊:
影响因子:
56.9
通讯作者:
Quake, SR
Quake, SR
中科院分区:
综合性期刊1区
文献类型:
--
作者:
Thorsen, T;Maerkl, SJ;Quake, SR

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我们开发了高密度的微流体芯片,其中包含有数千个微机械阀和数百个单独寻址室的管道网络。这些流体装置类似于采用大规模集成技术制造的电子集成电路。这些网络的一个关键组成部分是流体多路复用器,它是一个二元阀模式的组合阵列,通过允许以最少的输入数量进行复杂的流体操作,以指数方式增加了网络的处理能力。我们使用这些集成的微流体网络构建了一个比较器阵列的微流体模拟和一个行为类似于随机存取存储器的微流体存储设备。
We developed high-density micro fluidic chips that contain plumbing networks with thousands of micromechanical valves and hundreds of individually addressable chambers. These fluidic devices are analogous to electronic integrated circuits fabricated using large-scale integration. A key component of these networks is the fluidic multiplexor, which is a combinatorial array of binary valve patterns that exponentially increases the processing power of a network by allowing complex fluid manipulations with a minimal number of inputs. We used these integrated micro fluidic networks to construct the micro fluidic analog of a comparator array and a micro fluidic memory storage device whose behavior resembles random-access memory.