Depressive symptoms predict incident dementia during short-but not long-term follow-up period
Depressive symptoms predict incident dementia during short-but not long-term follow-up period
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DOI：
10.1016/j.jalz.2013.10.006
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发表时间：
2014-10-01
影响因子：
14
通讯作者：
Tiemeier, Henning
中科院分区：
文献类型：
--
作者：
Mirza, Saira Saeed;de Bruijn, Renee F. A. G.;Tiemeier, Henning
背景：抑郁症是痴呆的长期危险因素还是痴呆的前驱症状尚不清楚。因此，我们在以人群为基础的队列中通过短期和长期随访检查了抑郁症状和痴呆之间的关系。方法：在鹿特丹研究中，通过连续监测，对4393名非痴呆个体进行了13.7年的痴呆事件随访。使用不同时间间隔的Cox比例风险模型来估计发生痴呆的风险。结果：582名参与者在13.7年的时间里患上了痴呆症。在整个随访期间，有抑郁症状的人患痴呆的风险比没有抑郁症状的人高8%。在短期和中期随访中风险最高，尤其是男性。在超过10年的随访期间，我们没有发现两者之间的关联。结论：我们的研究结果表明，晚年抑郁症状是痴呆前驱症状的一部分，而不是痴呆的独立危险因素。(C) 2014阿尔茨海默病协会。版权所有。
Background: Whether depression is a long-term risk factor for dementia or represents a dementia prodrome is unclear. Therefore, we examined the relationship between depressive symptoms and dementia during short and long follow-up in a population-based cohort.Methods: In the Rotterdam Study, 4393 nondemented individuals were followed for incident dementia for 13.7 years by continuous monitoring. Cox proportional hazards models for different time intervals were used to estimate the risk of incident dementia.Results: Five-hundred eighty-two participants developed dementia during 13.7 years. Persons with depressive symptoms had an 8% increased risk of dementia compared with those without depressive symptoms during the overall follow-up. The risk was highest in the short and intermediate follow-up, particularly in men. We did not find an association in the follow-up period beyond 10 years.Conclusion: Our results suggest that late-life depressive symptoms are part of a dementia prodrome rather than an independent risk factor of dementia. (C) 2014 The Alzheimer's Association. All rights reserved.