Interaction of C1GALT1–IL5RA on the susceptibility to IgA nephropathy in Southern Han Chinese
Interaction of C1GALT1–IL5RA on the susceptibility to IgA nephropathy in Southern Han Chinese
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DOI：
10.1038/jhg.2012.133
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发表时间：
2012-11
影响因子：
3.5
通讯作者：
Wei Wang;Yu Sun;Yonggui Fu;Xueqing Yu;Ming Li
中科院分区：
文献类型：
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作者：
Wei Wang;Yu Sun;Yonggui Fu;Xueqing Yu;Ming Li
IGA肾病是世界上最常见的肾小球肾炎之一，被认为是多因素的复合性疾病，遗传和环境因素参与了该病的发生。以往的关联研究中单基因复制的失败可能是因为基因间的相互作用对复杂疾病的易感性有更大的影响。总共选择了24个候选基因中的31个单核苷酸多态(SNPs)，对527例IgAN患者和543名健康对照进行了大规模的病例对照研究。传统的线性Logistic回归分析被用来检测显性、隐性和加性遗传模型中的单基因座关联。采用Bonferroni校正法调整多项检测的P值。多因素降维(MDR)法检测多个SNPs的基因-基因互作效应。在Bonferroni校正后，在IgAN患者和对照组之间没有观察到显著的单基因座关联(Pc>；0.05)。多药耐药分析显示C1GALT1-330G/T(Rs1008898)和IL5RA31+197A/G(Rs340833)对IgAN(P<；0.001)的易感性存在潜在的交互作用。基因间的相互作用可能对IgA肾病的易感性有一定的影响。这一发现为未来的研究提供了一个潜在的基因-基因交互模型。
IgA nephropathy is one of the most common glomerulonephritis throughout the world, which is thought to be the multifactorial complex diseases, with genetic and environmental factors contributing to this disease. The failure of replicating the single genes in previous association studies may be of that the gene–gene interaction might have more influence on the susceptibility of the complex diseases. In all, 31 single-nucleotide polymorphisms (SNPs) in 24 candidate genes (which were involved in the pathways implicated in the development or progression of IgAN) were selected to conduct a large case–control association study in 527 IgAN patients and 543 healthy controls. Traditional linear logistic regression analyses were used to detect single-locus associations in dominant, recessive and additive genetic models. Bonferroni correction was used to adjust the P-values for multiple testing. The gene–gene interaction effects of multiple SNPs were detected by multifactor-dimensionality reduction (MDR) method. After Bonferroni correction, no significant single-locus associations was observed between IgAN patients and controls (Pc> 0.05). The MDR analysis showed a potential interaction of C1GALT1-330G/T (rs1008898) and IL5RA31+ 197A/G (rs340833) on the susceptibility of IgAN (P< 0.001). Gene–gene interaction may have some influence on the susceptibility to IgA nephropathy. This finding proposed a potential gene–gene interactive model for future studies.