Angina Pectoris at Rest with Preservation of Exercise Capacity: Prinzmetal's Variant Angina
Angina Pectoris at Rest with Preservation of Exercise Capacity: Prinzmetal's Variant Angina
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保持运动能力的静息心绞痛：Prinzmetal 的变异型心绞痛
DOI：
10.1161/01.cir.47.5.946
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发表时间：
1973
期刊：
影响因子：
37.8
通讯作者：
Anthony B. Alvaro
中科院分区：
文献类型：
--
作者：
R. Macalpin;A. Kattus;Anthony B. Alvaro
20例与普林茨梅尔特变异型心绞痛的描述和文献复习。这种综合征的特征是静息时心绞痛发作伴S-T段抬高，而运动能力保持良好。冠状动脉造影通常显示主要冠状动脉的显著的、局灶性的、阻塞性的疾病，这可以从发作期间ECG中看到的S-T升高的分布来预测。偶尔冠状动脉疾病很小或不存在。发作的原因被认为是主要冠状动脉的短暂性痉挛性闭塞，实际上在一个病例的手术中观察到了这一点。由于这种不寻常的病理生理学，这些患者可能不是孤立隐静脉旁路手术的理想候选人。其他诊断，治疗和预后的影响，这一有趣的心绞痛综合征进行了讨论。
Twenty patients with Prinzmetal's variant of angina are described and the literature on the subject is reviewed. This syndrome is characterized by anginal attacks at rest with S-T segment elevation, while exercise capacity is well preserved. Coronary arteriography usually demonstrates significant, focal, obstuctive disease of the major coronary artery predicted from the distribution of S-T elevation seen in the ECG during attacks. Occasionally the coronary disease is minimal or absent. The cause of attacks is believed to be transient, spastic occlusion of a major coronary artery, which was actually observed during surgery in one case. Because of this unusual pathophysiology, these patients may not make ideal candidates for isolated saphenous vein bypass surgery. Other diagnostic, therapeutic, and prognostic implications of this interesting anginal syndrome are discussed.