Vitamin D Intake and Brain Cortical Thickness in Community-Dwelling Overweight Older Adults: A Cross-Sectional Study.
Vitamin D Intake and Brain Cortical Thickness in Community-Dwelling Overweight Older Adults: A Cross-Sectional Study.
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DOI：
10.1093/jn/nxab168
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发表时间：
2021-06
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通讯作者：
S. Lefèvre-Arbogast;K. Dhana;N. Aggarwal;Shengwei Zhang;Puja Agarwal;Xiaoran Liu;N. Laranjo;V. Carey;F. Sacks;L. Barnes;K. Arfanakis
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作者：
S. Lefèvre-Arbogast;K. Dhana;N. Aggarwal;Shengwei Zhang;Puja Agarwal;Xiaoran Liu;N. Laranjo;V. Carey;F. Sacks;L. Barnes;K. Arfanakis
背景维生素D对大脑健康至关重要，是预防认知能力下降和阿尔茨海默病（AD）发作的有希望的候选药物，尽管潜在的大脑机制尚不清楚。本研究旨在确定维生素D摄入量与老年人大脑皮质厚度之间的关系。这是一项横断面调查，263名年龄在65岁及以上的认知未受损参与者参加了MIND（Mediterranean DASH干预神经退行性延迟）试验（一项正在进行的研究，测试3年饮食干预对认知下降的影响）。从饮食和补充剂中摄入的维生素D通过FFQ确定。线性回归分析，调整年龄，性别，种族，教育，收入，认知和身体活动，以及心血管疾病风险因素，用于确定维生素D摄入量与全脑，脑叶和AD特征的皮质厚度之间的关联。结果维生素D总摄入量与颞叶皮质厚度和AD特征相关。与维生素D总摄入量最低四分位数[中位数：140国际单位（IU）/d]的个体相比，最高四分位数（中位数：1439 IU/d）的个体颞叶厚0.038 mm（95% CI：0.006，0.069 mm），AD特征厚0.041 mm（95% CI：0.012，0.070 mm）。大多数维生素D的摄入来自补充剂，补充剂的摄入也与皮质厚度有关。与未使用补充剂的人相比，服用800-1000 IU/d和>1000 IU/d补充维生素D的人有0.039-mm（95% CI：0.013，0.066 mm）和0.047 mm（95% CI：0.013，0.081 mm）较厚的颞叶和0.037 mm（95% CI：0.013，0.061 mm）和0.046 mm（95% CI：0.015，0.077 mm）较厚的AD签名。在我们的样本中，膳食维生素D与脑皮质厚度无关。结论：在认知功能未受损的老年人中，维生素D的总摄入量和补充摄入量与易患AD的区域的皮质厚度相关。clinicaltrials.gov
BACKGROUND Vitamin D is critical to brain health and a promising candidate to prevent cognitive decline and onset of Alzheimer disease (AD), although the underlying brain mechanisms are unclear. OBJECTIVES This study aimed to determine the association between vitamin D intake and brain cortical thickness in older adults. METHODS This was a cross-sectional investigation of 263 cognitively unimpaired participants, aged 65 y and older, participating in the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) trial (an ongoing study testing the effects of a 3-y diet intervention on cognitive decline). Vitamin D intake, from diet and supplements, was ascertained from an FFQ. Linear regression analysis, adjusted for age, sex, race, education, income, cognitive and physical activities, and cardiovascular disease risk factors, was used to determine the association between vitamin D intake and cortical thickness of the whole brain, lobes, and AD signature. RESULTS Total vitamin D intake was associated with cortical thickness of the temporal lobe and AD signature. Compared with individuals in the lowest quartile of total vitamin D intake [median: 140 international units (IU)/d], those in the highest quartile (median: 1439 IU/d) had a 0.038-mm (95% CI: 0.006, 0.069 mm) thicker temporal lobe and 0.041-mm (95% CI: 0.012, 0.070 mm) thicker AD signature. Most vitamin D intake was from supplements, and supplemental intake was also associated with cortical thickness. Compared with those who used no supplement, individuals taking 800-1000 IU/d and >1000 IU/d of supplemental vitamin D had a 0.039-mm (95% CI: 0.013, 0.066 mm) and 0.047-mm (95% CI: 0.013, 0.081 mm) thicker temporal lobe and a 0.037-mm (95% CI: 0.013, 0.061 mm) and 0.046-mm (95% CI: 0.015, 0.077 mm) thicker AD signature, respectively. Dietary vitamin D was not related to brain cortical thickness in our sample. CONCLUSIONS In cognitively unimpaired older adults, total and supplemental vitamin D intakes were associated with cortical thickness in regions vulnerable to AD.This trial was registered at clinicaltrials.gov as NCT02817074.