Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit
Segmentation of the Four-Layered Retinal Vasculature Using High-Resolution Optical Coherence Tomography Angiography Reveals the Microcirculation Unit
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DOI：
10.1167/iovs.18-25301
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发表时间：
2018-12-01
影响因子：
4.4
通讯作者：
Tsujikawa, Akitaka
中科院分区：
文献类型：
--
作者：
Muraoka, Yuki;Uji, Akihito;Tsujikawa, Akitaka
目的.利用高分辨率光学相干断层扫描血管造影（HR-OCTA）对人黄斑区视网膜血管网的四层结构进行区分并观察其形态学特征。使用HR-OCTA设备扫描10名无眼部疾病的健康受试者的10只右眼的黄斑区域10次，测量为464 × 464像素。创建平均OCTA图像。基于清晰的去相关信号，分割四个血管板，包括视网膜神经纤维层（RNFL）、神经节细胞层（GCL）以及内核层（INL）的顶部和底部中的每一个。在每个板的定性特征和定量测量进行了比较，在传统的分割板。HR-OCTA分离了黄斑中的四层血管丛，其遵循相应的解剖层。视网膜神经纤维层的分割显示放射状的视乳头周围毛细血管（RPC）延伸到黄斑中心区。RPC遵循相对直和长的路径，几乎没有明显的馈电点和馈电线。GCL板增强了动脉和小动脉周围无毛细血管区的可视化，并有助于区分动脉和静脉系统。微动脉和微静脉由毛细血管连接，毛细血管以网状方式排列，具有多个小动脉供血点和动脉瘤。INL顶部和底部的血管丛由涡旋排列的毛细血管组成。这些涡旋排列的中心与GCL中的小静脉一致。HR-OCTA可以区分黄斑区的四层血管丛，并阐明其血管造影特征。
PURPOSE. To differentiate the four layers of the retinal vessel network in the human macula and examine their morphologic features using high-resolution optical coherence tomography angiography (HR-OCTA).METHODS. Macular areas measuring 464 x 464 pixels of 10 right eyes of 10 healthy subjects without ocular disease were scanned 10 times using a HR-OCTA device. Averaged OCTA images were created. Based on clear decorrelation signals, four vascular slabs were segmented, comprising one each in the retinal nerve fiber layer (RNFL), ganglion cell layer (GCL), and top and bottom of the inner nuclear layer (INL). Qualitative features and quantitative measurements in each slab were compared with those in conventionally segmented slabs.RESULTS. HR-OCTA isolated four layers of vascular plexuses in the macula that followed the corresponding anatomic layers. Segmentations for the RNFL revealed that radial peripapillary capillaries (RPCs) extended to the central macular area. The RPCs followed relatively straight and long paths, with few apparent feed points and anastomoses. The GCL slab enhanced visualization of the capillary-free zones around the arteries and arterioles and helped to differentiate arterial and venous systems. The arterioles and venules were linked by capillaries that were arranged in a mesh-like fashion, with multiple arteriolar feed points and anastomoses. Vascular plexuses in the top and bottom of the INL consisted of capillaries in a vortex arrangement. The center of these vortex arrangements was consistent with the venules in the GCL.CONCLUSIONS. HR-OCTA can differentiate the four layers of vascular plexuses in the human macula and elucidate their angiographic features.