The genetic mapping and gene structure of mouse paraoxonase/arylesterase.
The genetic mapping and gene structure of mouse paraoxonase/arylesterase.
复制标题
小鼠对氧磷酶/芳酯酶的遗传图谱和基因结构。
DOI：
10.1006/geno.1995.1261
复制
发表时间：
1995
期刊：
影响因子：
--
通讯作者：
LaDu,BN
中科院分区：
文献类型：
--
作者：
Sorenson,RC;Primo-Parmo,SL;Camper,SA;LaDu,BN
哺乳动物对氧磷酶/芳基酯酶的生理作用是未知的。然而，对氧磷酶是一种HDL相关蛋白，最近的研究表明它可能具有抗动脉粥样硬化的功能。我们描述了小鼠对氧磷酶基因（Pon 1）的染色体定位和结构，以建立Pon 1作为小鼠遗传决定性状或病理状态的候选基因。Pon 1的编码部分延伸超过约25-26 kb，由9个外显子和8个内含子组成。我们还提供了Pon 1 5′侧翼区的核苷酸序列，其中包含许多DNA结合蛋白的共有序列。单倍型分析的94个N2后代种间杂交表明，Pon 1是本地化的近端小鼠6号染色体附近的D 6 Mit 86。这种分配排除了Pon 1作为动脉粥样硬化易感基因Ath 1、Ath 2和Ath 3的候选者。然而，Pon 1是一个有希望的候选人，其余的未映射的Ath基因。
The physiological role of mammalian paraoxonase/arylesterase is unknown. However, paraoxonase is an HDL-associated protein, and recent studies indicate that it may have anti-atherogenic functions. We describe the chromosomal localization and structure of the mouse paraoxonase gene (Pon1) to establish Pon1 as a candidate gene for genetically determined traits or pathological states in the mouse. The coding portion of Pon1 extends over approximately 25-26 kb and consists of nine exons and eight introns. We also present nucleotide sequences from the 5′-flanking region of Pon1 containing numerous consensus sequences for DNA binding proteins. Haplotype analysis of 94 N2 progeny from an interspecific cross indicates that Pon1 is localized on proximal mouse chromosome 6 near D6Mit86. This assignment excludes Pon1 as a candidate for the atherosclerosis susceptibility genes Ath1, Ath2, and Ath3. However, Pon1 is a promising candidate for the remaining unmapped Ath genes.