Genetic Screening of the Mitochondrial Rho GTPases MIRO1 and MIRO2 in Parkinson's Disease.
Genetic Screening of the Mitochondrial Rho GTPases MIRO1 and MIRO2 in Parkinson's Disease.
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DOI：
10.2174/1874205x01206010001
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发表时间：
2012
期刊：
影响因子：
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通讯作者：
Belin AC
中科院分区：
文献类型：
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作者：
Anvret A;Ran C;Westerlund M;Sydow O;Willows T;Olson L;Galter D;Belin AC
MIRO1和MIRO2（线粒体Ras同源基因家族，成员T1和T2）也称为RHOT1和RHOT2，属于线粒体Rho GT3家族，并且参与神经元中线粒体的轴突运输。由于线粒体功能障碍与帕金森病（PD）密切相关，因此MIRO1和MIRO2可以被认为是PD的新候选基因。我们分析了两个非同义多态性和一个同义多态性MIRO1和两个非同义多态性MIRO2，在瑞典帕金森病例对照材料，包括241例患者和307神经健康对照。MIRO 1和MIRO 2的多态性与PD无显著相关性。虽然我们没有发现一个显着的关联与PD在我们的瑞典病例对照材料，我们不能排除这些Rho GTP酶作为候选基因PD或其他神经退行性疾病。
MIRO1 and MIRO2 (mitochondrial Ras homolog gene family, member T1 and T2) also referred to as RHOT1 and RHOT2, belong to the mitochondrial Rho GTPase family and are involved in axonal transport of mitochondria in neurons. Because mitochondrial dysfunction is strongly implicated in Parkinson’s disease (PD), MIRO1 and MIRO2 can be considered as new candidate genes for PD. We analyzed two non-synonymous polymorphisms and one synonymous polymorphism in MIRO1 and two non-synonymous polymorphisms in MIRO2, in a Swedish Parkinson case-control material consisting of 241 patients and 307 neurologically healthy controls. None of the analyzed polymorphisms in MIRO1 and MIRO2 were significantly associated with PD. Although we did not find a significant association with PD in our Swedish case-control material, we cannot exclude these Rho GTPases as candidate genes for PD or other neurodegenerative disorders.