Design and synthesis of periodic mesoporous organosilica materials with a multi-compartment structure
Design and synthesis of periodic mesoporous organosilica materials with a multi-compartment structure
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多室结构周期性介孔有机硅材料的设计与合成
DOI：
10.1039/c5ra16497d
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发表时间：
2015
期刊：
影响因子：
3.9
通讯作者：
ZHAO George Xiu Song
中科院分区：
文献类型：
--
作者：
LIN Chun Xiang Cynthia;JAMBHRUNKAR Siddharth;YUAN Pei;ZHOU Chun Hui Clayton;ZHAO George Xiu Song
最近，许多科学家对复制天然细胞中发现的多隔室的独特结构和功能感兴趣。尽管在为有机材料重新创建多室结构方面取得了成功，但将类似的概念转化为无机和混合材料以用于更多用途的应用仍然是一个巨大的挑战。在这里，作为有机硅家族中的第一个例子，我们提出了一种简便的合成路线，通过添加共溶剂的氟碳（FC）和烃（HC）表面活性剂的自发组装来创建具有多室结构的杂化材料。多隔室周期性介孔有机硅（MCPMO）的形成是由有机共溶剂的存在引发的，该有机共溶剂在系统中诱导渗透压差。MCPMO显示了抗疟疾和抗癌药物青蒿素的高负载能力（47%），由于其独特的区室化结构和疏水特性，具有可持续释放特性。这种合成策略可以扩展到设计具有不同组成和形态的各种材料，用于更广泛的应用，包括微电子，生物医学，催化和储能。
Recently many scientists are interested in replicating the unique structure and function of multi-compartments found in natural cells. Despite the success in recreating multi-compartment structures for organic materials, it is a great challenge to translate a similar concept into inorganic and hybrid materials for more versatile applications. Here, as the first example in the organosilica family, we present a facile synthesis route to create hybrid materials with a multi-compartment structure through the spontaneous assembly of fluorocarbon (FC) and hydrocarbon (HC) surfactants with the addition of co-solvent. The formation of multi-compartment periodic mesoporous organosilica (MCPMO) is triggered by the presence of organic co-solvent that induces an osmotic pressure difference in the system. The MCPMO demonstrates a high loading capacity of the antimalarial and anticancer drug artemisinin (47%) with a sustainable release profile attributed to the unique compartmentalized structure and hydrophobic properties. This synthesis strategy can be extended to design various materials with different compositions and morphologies for wider applications including microelectronics, biomedicine, catalysis and energy storage.