Patient-Reported Outcomes in Sentinel Node-Negative Adjuvant Breast Cancer Patients Receiving Sentinel-Node Biopsy or Axillary Dissection: National Surgical Adjuvant Breast and Bowel Project Phase III Protocol B-32
Patient-Reported Outcomes in Sentinel Node-Negative Adjuvant Breast Cancer Patients Receiving Sentinel-Node Biopsy or Axillary Dissection: National Surgical Adjuvant Breast and Bowel Project Phase III Protocol B-32
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DOI：
10.1200/jco.2010.28.2491
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发表时间：
2010-09-01
影响因子：
45.3
通讯作者：
Ganz, Patricia A.
中科院分区：
文献类型：
--
作者：
Land, Stephanie R.;Kopec, Jacek A.;Ganz, Patricia A.
目的前哨淋巴结切除术（SNR）与传统腋窝淋巴结清扫术（AD）相比，可降低术后并发症的发生率。国家外科辅助乳腺和肠道项目（NSABP）B-32是一项随机III期试验，比较了SNR立即继AD（SNAD）与SNR和随后的AD（如果SN为阳性）。我们报告明确的患者报告的结果（PRO）comparation.Patients和MethodsEligible患者临床淋巴结阴性，可手术浸润性乳腺癌。PRO子研究包括2001年5月至2004年2月在美国社区机构登记的所有SN阴性参与者（n = 749; 78%年龄>= 50; 87%临床肿瘤大小
PurposeSentinel lymph node resection (SNR) may reduce morbidity while providing the same clinical utility as conventional axillary dissection (AD). National Surgical Adjuvant Breast and Bowel Project (NSABP) B-32 is a randomized phase III trial comparing SNR immediately followed by AD (SNAD) to SNR and subsequent AD if SN is positive. We report the definitive patient-reported outcomes (PRO) comparisons.Patients and MethodsEligible patients had clinically node-negative, operable invasive breast cancer. The PRO substudy included all SN-negative participants enrolled May 2001 to February 2004 at community institutions in the United States (n = 749; 78% age >= 50; 87% clinical tumor size