Effect of Brij-78 on systemic delivery of insulin from an ocular device.
Effect of Brij-78 on systemic delivery of insulin from an ocular device.
复制标题
Brij-78 对从眼部装置全身输送胰岛素的影响。
DOI：
10.1021/js960423s
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发表时间：
1997
影响因子：
3.8
通讯作者：
Yalkowsky,SH
中科院分区：
文献类型：
--
作者：
Lee,YC;Simamora,P;Yalkowsky,SH
An ocular insert is developed for the controlled systemic delivery of insulin. Commercially available Gelfoam absorbable gelatin sponge, USP, is used in the fabrication of the ocular insert in the form of a matrix system. Two eyedrop formulations and 13 eye device formulations were evaluated. The efficacy of insulin ocular delivery was quantitated by monitoring the changes in its pharmacological response (i.e., blood glucose lowering). Thein vivoresults from devices containing 0.5 or 1.0 mg of insulin with 20 µg of polyoxyethylene-20-stearyl ether (Brij-78) give a substantial improvement in insulin activity and a significant prolongation in its duration compared with the eyedrops. In addition, the mean blood glucose concentration returns to nearly normal levels within 60 min after the removal of the device. Overall, the application of the Gelfoam device makes it feasible to obtain a prolonged systemic delivery of insulin within the desired therapeutic levels without the risk of hypoglycemia.‡
