Granulomatous angiitis of the central nervous system.
Granulomatous angiitis of the central nervous system.
复制标题
中枢神经系统肉芽肿性血管炎。
作者：
E. Kolodny;J. Rebeiz;V. Caviness;E. Richardson
在血管的非感染性炎症性疾病中，一种罕见的肉芽肿性血管炎几乎完全局限于中枢神经系统（CNS）。病灶为局灶性，常坏死，通常与多核巨细胞有关。在被Cravioto和Feigin描述为一种独特的临床病理实体之前，这种疾病被不同地命名为“Morbus Boeck”（Zollinger 2），“过敏性血管炎和过敏性肉芽肿病”（Churg和Strauss 3， Newman和Wolf 4）和“巨细胞动脉炎”（McCormick和Neubuerger 5）。据我们所知，到目前为止，已经报道了14例这种疾病，其中2例出现在马萨诸塞州总医院Cabot病例系列的临床病理讨论中。6,7这两个病例，以及最近在该院研究的另外两个病例，是本次交流的主题。典型病变的连续切片
AMONG the noninfective inflammatory diseases of the blood vessels is a rare form of granulomatous angiitis that is almost entirely confined to the central nervous system (CNS). The lesions, which are focal and often necrotizing, are generally associated with multinucleate giant cells. Before its delineation as a distinct clinicopathologic entity by Cravioto and Feigin, 1 the condition was variously designated as " Morbus Boeck " (Zollinger 2 ), "allergic angiitis and allergic granulomatosis" (Churg and Strauss, 3 Newman and Wolf 4 ) and "giantcell arteritis" (McCormick and Neubuerger 5 ). To our knowledge, 14 cases of the disorder have been reported up to now, 1,2,4-11 of which two appeared in the form of clinicopathologic discussions in the Cabot case series from the Massachusetts General Hospital. 6,7 These two cases, and two additional ones more recently studied at this hospital, are the subject of the present communication. Serial sections of typical lesions from one of the