Nine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection
Nine-factor-based immunohistochemistry classifier predicts recurrence for early-stage hepatocellular carcinoma after curative resection
复制标题
基于九因素的免疫组织化学分类器预测早期肝细胞癌治愈性切除后的复发
DOI：
10.1038/s41416-020-0864-0
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发表时间：
2020-05-07
影响因子：
8.8
通讯作者：
Shi Ying-Hong
中科院分区：
文献类型：
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作者：
Liu Wei-Ren;Tian Meng-Xin;Shi Ying-Hong
背景免疫评分在许多癌症中显示出有希望的预后价值。我们的目的是建立并验证免疫分类器，以预测接受根治性切除的肝细胞癌 (HCC) 患者根治性切除后的生存率。方法对 664 名巴塞罗那临床肝癌 (BCLC) 0 期或 A 期 HCC 患者进行免疫组织化学 (IHC) 分类器检测。然后通过最小绝对收缩和选择算子方法构建了基于九个特征的 HCC-IHC 分类器。评估了 HCC-IHC 分类器与患者结果之间的关联。在此，根据 Cox 回归系数生成列线图，并通过决策曲线分析进行评估。结果我们构建了基于九个特征的 HCC-IHC 分类器；训练队列中低 HCC-IHC 分类患者和高 HCC-IHC 分类患者的 5 年无复发生存率存在显着差异（分别为 46.7% 和 26.7%；P< 0.001）。基于HCC-IHC分类器的列线图比传统分期系统具有更好的准确性。结论 总之，HCC-IHC分类器可以有效预测早期HCC患者的复发，并补充了BCLC分期系统的预后价值。 HCC-IHC 分类器可以促进患者决策并对早期 HCC 术后患者进行个体化管理。
BackgroundImmunoscore have shown a promising prognostic value in many cancers. We aimed to establish and validate an immune classifier to predict survival after curative resection of hepatocellular carcinoma (HCC) patients who have undergone curative resection.MethodsThe immunohistochemistry (IHC) classifier assay was performed on 664 patients with Barcelona Clinic Liver Cancer (BCLC) stage 0 or A HCC. A nine-feature-based HCC-IHC classifier was then constructed by the least absolute shrinkage and selection operator method. The associations between the HCC-IHC classifier and patient outcomes were assessed. Herein, a nomogram was generated from the Cox regression coefficients and evaluated by decision curve analysis.ResultsWe constructed an HCC-IHC classifier based on nine features; significant differences were found between the low-HCC-IHC classifier patients and high-HCC-IHC classifier patients in the training cohort in the 5-year relapse-free survival rates (46.7% vs. 26.7%, respectively;P< 0.001). The HCC-IHC classifier-based nomogram presented better accuracy than traditional staging systems.ConclusionsIn conclusion, the HCC-IHC classifier could effectively predict recurrence in early-stage HCC patients and supplemented the prognostic value of the BCLC staging system. The HCC-IHC classifier may facilitate patient decision-making and individualise the management of postoperative patients with early-stage HCC.