Airway luminal liquid. Sources and role as an amplifier of bronchoconstriction.
Airway luminal liquid. Sources and role as an amplifier of bronchoconstriction.
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气道管腔液体。
DOI：
10.1164/ajrccm/143.3_pt_2.s52
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Drazen,JM
中科院分区：
文献类型：
--
作者：
Yager,D;Shore,S;Drazen,JM
炎症细胞向气道腔释放介质可引发一系列导致气道阻塞的事件，特别是平滑肌收缩以及内皮和上皮通透性的改变，导致粘膜水肿和随后液体流入气道腔。在本报告中，我们简要回顾了几种炎症介质的影响，包括类二十烷酸、血小板活化因子和组胺，以及由于炎症介质的存在而可能二次释放的血浆蛋白和速激肽对内皮和上皮通透性的影响。然后我们考虑物理机制，由此产生的气道腔液体可以放大先前由于平滑肌收缩而收缩的气道的反应。具体来说，肌肉收缩期间形成的上皮突起之间的间隙中的液体可以通过以下方式放大管腔妥协的程度：（1）通过占据空间进一步减小管腔横截面积，以及（2）由于气液界面的表面张力而提供额外的向内反冲源。 AM 修订呼吸 DIS 1991； 143：S52-S54
The release of mediators from inflammatory cells into the airway lumen can initiate aseries of events leading to airway obstruction, particularly smooth muscle contraction and alteration of endothelial and epithelial permeability leading to mucosal edema and subsequent Influx of liquid into the airway lumen. In this report we briefly review the effects of several Inflammatory mediators, including eicosanoids, platelet-activating factor, and histamine, as well as the effects of plasma proteins and tachyklnins that may be secondarily released because of the presence of inflammatory mediators on endothelial and epithelial permeability. Wethen consider physical mechanisms whereby the resulting airway luminal liquid could amplify the response of an airway previously constricted because of smooth muscle contraction. Specifically, liquid in the Interstices between epithelial projections that are formed during muscular contraction could amplify the degree of luminal compromise by (1) further decreasing luminal cross-sectional area by occupying space, and (2) providing an additional source of Inward recoil because of the surface tension of the airliquid Interface. AM REV RESPIR DIS 1991; 143: S52-S54