Orbitofrontal, dorsal striatum, and habenula functional connectivity in psychiatric patients with substance use problems.
Orbitofrontal, dorsal striatum, and habenula functional connectivity in psychiatric patients with substance use problems.
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DOI：
10.1016/j.addbeh.2020.106457
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发表时间：
2020-04
影响因子：
4.4
通讯作者：
Hyuntaek Oh;Jaehoon Lee;Savannah N. Gosnell;M. Patriquin;T. Kosten;R. Salas
中科院分区：
文献类型：
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作者：
Hyuntaek Oh;Jaehoon Lee;Savannah N. Gosnell;M. Patriquin;T. Kosten;R. Salas
药物滥用通常被定义为尽管有不良后果但仍持续使用药物。最近的临床前研究表明，从眶额皮质（OFC）到背侧纹状体的更高输入与强迫性奖励寻求行为有关，尽管有负面影响。目前尚不清楚药物使用是否与人类OFC和背侧纹状体之间的连接有关。我们研究了高（PU，问题用户）和低（LU，低用户）物质使用的精神病住院患者的OFC，背侧纹状体和缰（和整个大脑在一个单独的分析）之间的静息状态功能连接（RSFC）。我们匹配了PU和LU的精神共病。我们发现，PU表现出较高的RSFC之间的左侧OFC和左侧背侧纹状体比LU。PU组缰核与眶额皮层和背侧纹状体之间的RSFC也较高，这表明缰核可能是同一回路的一部分。最后，在PU中也观察到OFC和OFC之间较高的RSFC。我们的数据表明，OFC，缰核，背侧纹状体，背侧纹状体可能在PU中发挥重要作用。此外，我们假设，缰可能连接中脑边缘和皮质纹状体系统，这是改变PU。
Substance abuse is commonly defined as the persistence of drug use despite negative consequences. Recent preclinical work has shown that higher input from the orbitofrontal cortex (OFC) to the dorsal striatum was associated with compulsive reward-seeking behavior despite negative effects. It remains unknown whether drug use is associated with the connectivity between the OFC and dorsal striatum in humans. We studied the resting state functional connectivity (RSFC) between the OFC, dorsal striatum, and habenula (and the whole brain in a separate analysis) in psychiatric inpatients with high (PU, problem users) and low (LU, low users) substance use. We matched PU and LU for psychiatric comorbidities. We found that PU showed higher RSFC between the left OFC and the left dorsal striatum than LU. RSFC between the habenula and both OFC and dorsal striatum was also higher in PU, which suggests the habenula may be a part of the same circuit. Finally, higher RSFC between the OFC and insula was also observed in PU. Our data shows that OFC, habenula, dorsal striatum, and insula may play an important role in PU. Furthermore, we postulate that the habenula may link the mesolimbic and cortico-striatal systems, which are altered in PU.