PULMONARY DISTRIBUTION OF PARTICLES GIVEN BY INTRATRACHEAL INSTILLATION OR BY AEROSOL INHALATION
PULMONARY DISTRIBUTION OF PARTICLES GIVEN BY INTRATRACHEAL INSTILLATION OR BY AEROSOL INHALATION
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DOI：
10.1016/0013-9351(76)90107-9
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发表时间：
1976-01-01
影响因子：
8.3
通讯作者：
DAVIS, MA
中科院分区：
文献类型：
--
作者：
BRAIN, JD;KNUDSON, DE;DAVIS, MA
In animal studies concerned with the deposition of particulate matter [e.g., air pollutants, carcinogens, radioactive particles] in the lung, 2 methods for delivery of particles are commonly used, aerosol inhalation and intratracheal instillation of particle suspensions. An attempt was made to evaluate the distribution patterns of each of these methods. Particles labeled with 99mTc were administered to both rats and hamsters. The animals were subsequently killed. The lungs were excised, weighed, inflated, dried and divided into 54 pieces which were counted individually in a Nuclear-Chicago Model 4230 Automatic Gamma Scintillation System. Groups receiving intratracheal instillations demonstrated nonuniform distribution patterns with preferential deposition in the dependent portions of the lung. The aerosol groups evidence more even distribution with preferential deposition in the apical lobes. [Animal experiments often attempt to simulate human exposure to particulate matter.].
