Relationship between electroneurographic changes and serum ubiquitin levels in patients with type 2 diabetes
Relationship between electroneurographic changes and serum ubiquitin levels in patients with type 2 diabetes
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DOI：
10.2337/diacare.24.1.100
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发表时间：
2001-01-01
期刊：
影响因子：
16.2
通讯作者：
Ünüvar, N
中科院分区：
文献类型：
--
作者：
Akarsu, E;Pirim, I;Ünüvar, N
目的 - 本研究的目的是调查 2 型糖尿病患者血清泛素水平与周围神经神经电图变化之间的关系。 研究设计和方法 - 该研究涉及 34 名 2 型糖尿病患者（19 名男性，15 名女性；平均年龄 46 +/- 13 岁）。通过夹心酶联免疫吸附测定法测量血清泛素值。对三个运动神经（正中神经、胫神经和腓神经）和三个感觉神经（正中神经、尺神经和腓肠神经）进行神经传导速度 (NCV) 测量。运动复合肌肉动作电位 (CMAP) 值由中位、胫骨和腓骨运动神经振幅之和计算得出，感觉复合神经动作电位 (CNAP) 计算为中位和尺感觉神经振幅之和。 结果 - 糖尿病患者分为三组：第 1 组 (n = 8) 神经电图结果正常，第 2 组 (n = 8) NCV 减慢，第 3 组 (n = 18) 神经电图结果较低运动 CMAP 和/或感觉 CNAP 的值以及减慢的 NCV。第 3 组的平均泛素水平 (20.4 +/- 2.9 ng/dl) 显着高于第 1 组 (11.2 +/- 1.1 ng/dl，t = 11.5，P < 0.0001) 和第 2 组 (13.2 2.7 ng/dl，t = 5.9，P < 0.0001)。血清泛素水平与运动 CMAP (r = -0.68) 和感觉 CNAP (r = -0.61) 值呈负相关。 结论 - 这项研究的结果表明，2 型糖尿病患者周围神经轴突振幅减小与血清泛素水平升高之间可能存在相关性。需要进一步的研究来证实这种关系。
OBJECTIVE - The aim of the present study was to investigate any relationship between serum ubiquitin levels and electroneurographic changes in peripheral nerves for patients with type 2 diabetes.RESEARCH DESIGN AND METHODS - The study involved 34 patients (19 men, 15 women; mean age 46 +/- 13 years) with type 2 diabetes. Serum ubiquitin values were measured by sandwich enzyme-linked immunosorbent assay. Measurement of nerve conduction velocity (NCV) was performed on three motor (median, tibial, and peroneal) and three sensory (median, ulnar, and sural) nerves. The value of motor compound muscle action potential (CMAP) was obtained from the sum of median, tibial, and peroneal motor nerve amplitudes, and sensory compound nerve action potential (CNAP) was computed as the sum of median and ulnar sensory nerve amplitudes.RESULTS - Patients with diabetes were divided into three groups: group 1 (n = 8) had normal electroneurography results, group 2 (n = 8) had slowed NCV and group 3 (n = 18) had low values of motor CMAP and/or sensory CNAP as well as slowed NCV. Mean ubiquitin level in group 3 (20.4 +/- 2.9 ng/dl) was significantly higher than that in group 1 (11.2 +/- 1.1 ng/dl, t = 11.5, P < 0.0001) and group 2 (13.2 2.7 ng/dl, t = 5.9, P < 0.0001). Serum ubiquitin levels were inversely correlated with motor CMAP (r = -0.68) and sensory CNAP (r = -0.61) values.CONCLUSIONS - The results of this study indicate that there could be a relationship between the diminished amplitudes of axons of the peripheral nerve and the increase in serum ubiquitin levels in patients with type 2 diabetes. Further studies are required to confirm this relationship.