STRUCTURE OF THE HUMAN TYPE-I INTERFERON GENE-CLUSTER DETERMINED FROM A YAC CLONE CONTIG
STRUCTURE OF THE HUMAN TYPE-I INTERFERON GENE-CLUSTER DETERMINED FROM A YAC CLONE CONTIG
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DOI：
10.1006/geno.1994.1427
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发表时间：
1994-08-01
期刊：
影响因子：
4.4
通讯作者：
OLOPADE, OI
中科院分区：
文献类型：
--
作者：
DIAZ, MO;POMYKALA, HM;OLOPADE, OI
利用YAC克隆的重叠群构建了位于人9号染色体短臂（9p）上的I型干扰素基因簇的图谱。这张图包含26个干扰素（IFN）基因和假基因，它占了所有，除了一个，IFN序列以前报道的其他作者，加上一个新的IFNW假基因。9 p上最远端的基因是IFNB，最近端的基因是IFNWP19。20个最远端IFN序列的转录方向朝向端粒，6个最近端序列的转录方向朝向着丝粒。集群的几个区域显示出祖先复制事件的证据。这些事件中的一些可以解释为相邻串联基因之间的不平等交换。还确定了簇内几个断点的位置，这些断点来自与白血病和神经胶质瘤相关的缺失。(C)学术出版社
A map of the type-I interferon gene cluster located on the short arm of human chromosome 9 (9p) has been constructed using a contig of YAC clones. This map contains 26 interferon (IFN) genes and pseudogenes, and it accounts for all, except one, of the IFN sequences previously reported by other authors, plus a new IFNW pseudogene. The most distal gene on 9p is IFNB, and the most proximal one is IFNWP19. The direction of transcription for the 20 most distal IFN sequences is toward the telomere and for the 6 most proximal sequences, toward the centromere. Several regions of the cluster show evidence of ancestral duplication events. Some of these events may be explained by unequal crossing over between adjacent tandem genes. The location of several breakpoints within the cluster, from deletions associated with leukemias and gliomas, was also determined. (C) Academic Press, Inc.