Impact of bacterial pneumonia and Pneumocystis carinii pneumonia on human immunodeficiency virus disease progression. Pulmonary Complications of HIV Study Group.
Impact of bacterial pneumonia and Pneumocystis carinii pneumonia on human immunodeficiency virus disease progression. Pulmonary Complications of HIV Study Group.
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细菌性肺炎和卡氏肺囊虫肺炎对人类免疫缺陷病毒疾病进展的影响。
DOI：
10.1086/598629
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Hopewell,PC
中科院分区：
文献类型：
--
作者：
Osmond,DH;Chin,DP;Glassroth,J;Kvale,PA;Wallace,JM;Rosen,MJ;Reichman,LB;Poole,WK;Hopewell,PC
在一项HIV感染的多城市队列研究中检查了化脓性细菌和卡氏肺孢子虫引起的肺炎的病程。150例初次细菌性肺炎患者的中位生存期为24个月，而299例人类免疫缺陷病毒（HIV）感染的对照组受试者的中位生存期为37个月（P<0.001）。152例P.与280例匹配的对照组受试者的30个月相比，卡氏肺结核患者的中位生存期为23个月（P= .002）。尽管细菌性肺炎患者中位CD4淋巴细胞计数较高，但两种肺炎患者的中位生存期仅相差47天。这些结果表明，bothP.卡氏肺结核和细菌性肺炎与明显恶化的随后HIV病程相关。一次细菌性肺炎发作与一次AIDS定义的机会性感染后的预后相似，以及与CD4淋巴细胞计数>200相关的病例比例表明，应强调预防细菌性肺炎的措施。
The course of pneumonia caused by pyogenic bacteria andPneumocystis cariniiwas examined in a multicity cohort study of HIV infection. The median duration of survival among 150 individuals following initial bacterial pneumonia was 24 months, compared with 37 months among 299 human immunodeficiency virus (HIV)-infected control subjects matched by study site and CD4 lymphocyte count (P< .001). For 152 subjects withP. cariniipneumonia, median survival was 23 months, compared with 30 months for 280 matched control subjects (P= .002). Median durations of survival associated with the two types of pneumonia differed by only 47 days, despite a higher median CD4 lymphocyte count associated with bacterial pneumonia. These results suggest that bothP. cariniipneumonia and bacterial pneumonia are associated with a significantly worse subsequent HIV disease course. The similarity of prognosis after one episode of bacterial pneumonia vs. an AIDS-defining opportunistic infection and the proportion of cases occurring in association with a CD4 lymphocyte count of >200 suggest that measures to prevent bacterial pneumonia should be emphasized.