Conditioning, habituation and behavioral reorganization factors in chronic cocaine effects.
Conditioning, habituation and behavioral reorganization factors in chronic cocaine effects.
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慢性可卡因作用的调节、习惯和行为重组因素。
DOI：
10.1016/s0166-4328(05)80159-7
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发表时间：
1992
影响因子：
2.7
通讯作者：
Carey,RJ
中科院分区：
文献类型：
--
作者：
Damianopoulos,EN;Carey,RJ
大鼠给予可卡因（50.0 mg/kg i. p.）每天一次，持续7天，在开放场测试环境中放置20分钟之前立即（配对组）或放置30分钟之后（未配对组）。停药7天后，每隔3天对动物进行重新测试，一次用盐水，一次用可卡因（50 mg/kg）。测量运动的距离穿越（米）揭示了一个更高水平的运动在配对组的所有测试试验。配对与未配对差异的分析表明，可卡因的抗习惯化作用，而不是hypermotortion或条件运动效应。每只动物的旋转模式分析显示，到第5天，配对组（但非配对组）中四种直径尺寸的旋转频率分布出现新的频率分布。这种新模式的特征在于偏斜度向直径≥55 cm的大旋转方向偏移。这些旋转模式的质的变化指向一个特定的背景下的行为重组过程，以响应重复可卡因药物治疗。
Rats were administered cocaine (50.0 mg/kg i.p.) daily for 7 days in a Pavlovian paradigm either immediately prior (paired group) or 30 min following (unpaired group) a 20-min placement in an open field test environment. After 7 days of drug withdrawal, the animals were retested 3 days apart, once with saline and once with cocaine (50 mg/kg). Measurement of locomotion as distance traversed (m) revealed a higher level of locomotion in the paired group on all test trials. Analysis of the paired vs. unpaired differences indicated an antihabituation effect of cocaine rather than a hyperlocomotion or a conditioned locomotor effect. Rotation pattern analysis for each animal showed a new frequency distribution of rotations across four categories of diameter size in the paired but not in the unpaired group by Day 5. This new pattern was characterized by a shift in skewness toward large ≥55 cm diameter rotations. These qualitative changes in rotation pattern point to a context specific behavioral reorganization process in response to repeated cocaine drug treatment.