REACTIVE OXYGEN SPECIES AND ANTIOXIDANT VITAMINS - MECHANISMS OF ACTION
REACTIVE OXYGEN SPECIES AND ANTIOXIDANT VITAMINS - MECHANISMS OF ACTION
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DOI：
10.1016/0002-9343(94)90292-5
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发表时间：
1994-09-26
影响因子：
5.9
通讯作者：
FREI, B
中科院分区：
文献类型：
--
作者：
FREI, B
本文综述了活性氧在生物系统中的产生机制，以及各种抗氧化防御系统对生物大分子的氧化损伤提供保护。本文以人体低密度脂蛋白的氧化修饰及其维生素C、维生素E和β -胡萝卜素的预防为例，阐述了脂质过氧化和抗氧化保护的机制。
This article is a brief overview of the mechanisms of production of reactive oxygen species in biologic systems, and the various antioxidant defense systems that provide protection against oxidative damage to biologic macromolecules. The mechanisms of Lipid peroxidation and antioxidant protection are explained using a specific example, viz., oxidative modification of human low density lipoprotein and its prevention by vitamin C, vitamin E, and beta-carotene.