Assessment of Microelastic Properties of Bone Using Scanning Acoustic Microscopy: A Face-to-Face Comparison with Nanoindentation
Assessment of Microelastic Properties of Bone Using Scanning Acoustic Microscopy: A Face-to-Face Comparison with Nanoindentation
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DOI：
10.1143/jjap.48.07gk01
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发表时间：
2009-07-01
影响因子：
1.5
通讯作者：
Laugier, Pascal
中科院分区：
文献类型：
--
作者：
Rupin, Fabienne;Saied, Amena;Laugier, Pascal
目前的工作旨在比较，在现场匹配的皮质骨组织，微米级弹性模量E（a）从200兆赫扫描声显微镜（SAM）声阻抗（Z）结合骨矿物质密度（评估同步辐射微计算机断层扫描，SR-mu CT）纳米压痕模量E（n）。在En和Z之间观察到良好的相关性（R（2）= 0.67，p < 0.0001，均方根误差RMSE = 1.9GPa）。与纳米压痕模量相比，从Z导出的声学弹性模量E（a）显示出更高的E值。我们假设，E（a）和E（n）值之间的差异可能是由于泊松比的固定假设值，而文献中已报道的值介于0.15和0.45之间。尽管存在这些差异，但发现E（a）和E（n）之间存在高度显著的相关性（R（2）= 0.66，p < 0.001，RMSE = 1.8 GPa），表明SAM可以可靠地用作定量绘制组织水平骨弹性局部变化的模式。(C)2009日本应用物理学会
The current work aimed at comparing, on site-matched cortical bone tissue, the micron-level elastic modulus E(a) derived from 200 MHz-scanning acoustic microscopy (SAM) acoustic impedance (Z) combined with bone mineral density (assessed by synchrotron radiation microcomputed tomography, SR-mu CT) to nanoindentation modulus E(n). A good correlation was observed between En and Z (R(2) = 0.67, p < 0.0001, root mean square error RMSE = 1.9 GPa). The acoustical elastic modulus E(a) derived from Z showed higher values of E compared to nanoindentation moduli. We assumed that the discrepancy between E(a) and E(n) values may likely be due to the fixed assumed value of Poisson's ratio while values comprised between 0.15 and 0.45 have been reported in the literature. Despite these differences, a highly significant correlation between E(a) and E(n) was found (R(2) = 0.66, p < 0.001, RMSE = 1.8 GPa) suggesting that SAM can reliably be used as a modality to quantitatively map the local variations of tissue-level bone elasticity. (C) 2009 The Japan Society of Applied Physics