Cp*Co(III)-catalyzed direct functionalization of aromatic C-H bonds with α-diazomalonates
Cp*Co(III)-catalyzed direct functionalization of aromatic C-H bonds with α-diazomalonates
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CpCo(III) 催化芳香族 C-H 键与 α-重氮丙二酸酯的直接官能化
DOI：
10.1016/j.tetlet.2015.05.025
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发表时间：
2015-07-01
影响因子：
1.8
通讯作者：
Wang, Honggen
中科院分区：
文献类型：
--
作者：
Liu, Xu-Ge;Zhang, Shang-Shi;Wang, Honggen
采用直接C-H官能化逻辑，发展了Cp*Co（III）催化的（杂）芳烃与α-重氮丙二酸酯的分子间C（sp（2））-C（sp（3））组装.在吡唑基和嘧啶基导向基团的辅助下，一系列（杂）芳烃在相对温和和操作简单的反应条件下进行了有效的烷基化。发现良好的官能团耐受性、令人满意的产率和优异的区域选择性。（C）2015 Elsevier Ltd.保留所有权利。
Cp*Co(III)-catalyzed intermolecular C(sp(2))-C(sp(3)) assembly of (hetero)arenes with alpha-diazomalonates using a direct C-H functionalization logic was developed. A series of (hetero)arenes underwent alkylation efficiently under the assistance of pyrazolyl and pyrimidyl directing groups under relatively mild and operationally simple reaction conditions. Good functional group tolerance, satisfactory yields, and excellent regioselectivity were found. (C) 2015 Elsevier Ltd. All rights reserved.