Subfracture insult to a knee joint causes alterations in the bone and in the functional stiffness of overlying cartilage
Subfracture insult to a knee joint causes alterations in the bone and in the functional stiffness of overlying cartilage
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DOI：
10.1002/jor.1100150319
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发表时间：
1997-05-01
影响因子：
2.8
通讯作者：
Haut, RC
中科院分区：
文献类型：
--
作者：
Newberry, WN;Zukosky, DK;Haut, RC
目前汽车工业用于预测关节损伤的标准是基于骨折，但临床研究表明，慢性疾病，如骨关节病，可发生从一个单一的钝性损伤而不骨折，在本研究中，钝性损伤被传递到兔的髌股关节而不产生骨折。对损伤后不同时间的关节组织进行生物力学和组织学研究，通过力学压痕实验测量外侧关节面髌后软骨的功能完整性，并通过组织学切片测量软骨下骨的厚度。在典型动物中，软骨下骨的厚度在损伤后随着时间的推移而增加：并且在12个月时骨显示出显著增厚。损伤后12个月，软骨的机械刚度无明显变化。
The current criteria used by the automotive industry for predicting joint injury are based on fracture of bone, but clinical studies suggest that chronic diseases such as osteoarthrosis can occur from a single blunt insult without bone fracture, In the current study, blunt insults were delivered to the patellofemoral joints of rabbits without producing bone fractures. Biomechanical and histological studies were performed on joint tissues at various times after insult, The functional integrity of the retropatellar cartilage on the lateral facet was measured with mechanical indentation experiments, and the thickness of the subchondral bone was measured from histological sections, Impacts produced surface lesions on the retropatellar cartilage, The thickness of the subchondral bone in representative animals tended to increase with time after insult: and the bone exhibited significant thickening at 12 months. The overlying cartilage showed signs of degeneration, However, the mechanical stiffness of the cartilage did not change until 12 months after the insult.