Mechanical Characterization and Constitutive Modeling of Human Trachea: Age and Gender Dependency.
Mechanical Characterization and Constitutive Modeling of Human Trachea: Age and Gender Dependency.
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DOI：
10.3390/ma9060456
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发表时间：
2016-06-08
期刊：
影响因子：
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通讯作者：
Shadmehr MB
中科院分区：
文献类型：
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作者：
Safshekan F;Tafazzoli-Shadpour M;Abdouss M;Shadmehr MB
气管疾病通常会减少自由腔直径或壁硬度，从而限制气流。气管组织工程似乎是一个有前途的治疗这些疾病。制备的支架与天然气管所需的机械相容性需要研究人气管的机械行为。本研究旨在对人体气管进行力学表征，并根据年龄和性别对结果进行比较。在分离30个人气管后，对气管软骨、平滑肌和结缔组织样品进行单轴拉伸，以获得力-位移曲线并计算应力-拉伸数据。在几种模型中，Yeoh和Mooney-Rivlin超弹性函数能够最好地描述所有三个气管组件的超弹性行为。测得人气管软骨的弹性模量平均值为16.92 ± 8.76MPa。随着年龄的增长，观察到整体气管硬化，软骨的情况下，最显着的差异。因此，我们注意到随着年龄的增长，软骨和结缔组织中的一些组织学改变，这可能在与年龄相关的气管硬化中起作用。未观察到性别对气管组件的机械行为有显著影响。本研究结果可用于气管组织工程支架的设计和制备。
Tracheal disorders can usually reduce the free lumen diameter or wall stiffness, and hence limit airflow. Trachea tissue engineering seems a promising treatment for such disorders. The required mechanical compatibility of the prepared scaffold with native trachea necessitates investigation of the mechanical behavior of the human trachea. This study aimed at mechanical characterization of human tracheas and comparing the results based on age and gender. After isolating 30 human tracheas, samples of tracheal cartilage, smooth muscle, and connective tissue were subjected to uniaxial tension to obtain force-displacement curves and calculate stress-stretch data. Among several models, the Yeoh and Mooney-Rivlin hyperelastic functions were best able to describe hyperelastic behavior of all three tracheal components. The mean value of the elastic modulus of human tracheal cartilage was calculated to be 16.92 ± 8.76 MPa. An overall tracheal stiffening with age was observed, with the most considerable difference in the case of cartilage. Consistently, we noticed some histological alterations in cartilage and connective tissue with aging, which may play a role in age-related tracheal stiffening. No considerable effect of gender on the mechanical behavior of tracheal components was observed. The results of this study can be applied in the design and fabrication of trachea tissue engineering scaffolds.