An FFP:PRBC Transfusion Ratio ≥1:1.5 Is Associated With A Lower Risk Of Mortality After Massive Transfusion
An FFP:PRBC Transfusion Ratio ≥1:1.5 Is Associated With A Lower Risk Of Mortality After Massive Transfusion
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DOI：
10.1097/ta.0b013e3181878028
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发表时间：
2008-11-01
影响因子：
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通讯作者：
Moore, Ernest E.
中科院分区：
文献类型：
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作者：
Sperry, Jason L.;Ochoa, Juan B.;Moore, Ernest E.
目的：凝血障碍、体温过低和酸中毒的有害影响被描述为创伤性出血后死亡的标志。最近的军事经验表明，高新鲜冰冻血浆(FFP)：红细胞(PRBC)输血比例可以改善预后；然而，在平民创伤人群中应该给予这些输血产品的适当比例仍有待确定。方法：数据来自一项多中心前瞻性队列研究，评估钝性损伤成人失血性休克的临床结果。结果：严重钝性伤后12小时内输注1：1.50 FFP：PRBC(高F：P值，n=102)的患者与输注8单位血的患者相比，FFP：PRBC=1：1.5的死亡风险显著降低，但发生急性呼吸窘迫综合征的风险增加。死亡风险的降低与受伤后48小时内的死亡率最相关。这些结果表明，与FFP/PRBC比率相关的死亡风险
Objective: The detrimental effects of coagulopathy, hypothermia, and acidosis are well described as markers for mortality after traumatic hemorrhage. Recent military experience suggests that a high fresh frozen plasma (FFP):packed red blood cell (PRBC) transfusion ratio improves outcome; however, the appropriate ratio these transfusion products should be given remains to be established in a civilian trauma population.Methods: Data were obtained from a multicenter prospective cohort study evaluating clinical outcomes in blunt injured adults with hemorrhagic shock. Those patients who required >= 8 units PRBCs within the first 12 hours postinjury were analyzed (n = 415).Results: Patients who received transfusion products in >= 1:1.50 FFP:PRBC ratio (high F:P ratio, n = 102) versus = 8 units of blood after serious blunt injury, an FFP:PRBC transfusion ratio >= 1: 1.5 was associated with a significant lower risk of mortality but a higher risk of acute respiratory distress syndrome. The mortality risk reduction was most relevant to mortality within the first 48 hours from the time of injury. These results suggest that the mortality risk associated with an FFP:PRBC ratio