Laminar processing of numerosity supports a canonical cortical microcircuit in human parietal cortex.
Laminar processing of numerosity supports a canonical cortical microcircuit in human parietal cortex.
复制标题
数量的层流处理支持人类顶叶皮层中的典型皮层微电路。
DOI：
10.1016/j.cub.2021.07.082
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发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Dumoulin,SergeO
中科院分区：
文献类型：
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作者：
vanDijk,JelleA;Fracasso,Alessio;Petridou,Natalia;Dumoulin,SergeO
当神经信号在视觉层次中传递时，空间精度降低，刺激特征的特异性增加。在V1的层流处理中发现了1-4A类似的层次结构，其中来自丘脑的信息主要针对中央层，而空间精度降低，特征特异性向浅层和深层增加。5 - 17这种层流处理方案被认为是一种典型的皮层微电路，它在整个皮层上是相似的。11,18 - 21在这里，我们超越了早期的视觉皮层，并研究了在顶叶关联皮层中对数字（一组物品的集合大小）的处理是否遵循这一假设。数字处理涉及许多任务，如多目标跟踪、数学、决策和分散注意力。27顶叶联合皮层中的神经元被调谐到数字，具有首选的数字调谐和调谐宽度（即特异性）。28 - 30我们通过超高场功能磁共振成像和基于群体接受场的数量建模，量化了顶叶关联皮层各皮层深度的首选数量反应。1,28,31我们发现，数响应变得尖锐，即变得越来越具体，远离中心层。这表明，顶叶皮层中数字处理的层流处理机制与初级视觉皮层相似，为初级视觉皮层之外的典型皮层微回路假说提供了支持。
As neural signals travel through the visual hierarchy, spatial precision decreases and specificity for stimulus features increases.1–4A similar hierarchy has been found for laminar processing in V1, where information from the thalamus predominantly targets the central layers, while spatial precision decreases and feature specificity increases toward superficial and deeper layers.5–17This laminar processing scheme is proposed to represent a canonical cortical microcircuit that is similar across the cortex.11,18–21Here, we go beyond early visual cortex and investigate whether processing of numerosity (the set size of a group of items) across cortical depth in the parietal association cortex follows this hypothesis. Numerosity processing is implicated in many tasks such as multiple object tracking,22mathematics,23–25decision making,26and dividing attention.27Neurons in the parietal association cortex are tuned to numerosity, with both a preferred numerosity tuning and tuning width (i.e., specificity).28–30We quantified preferred numerosity responses across cortical depth in the parietal association cortex with ultra-high field fMRI and population receptive field-based numerosity modeling.1,28,31We find that numerosity responses sharpen, i.e., become increasingly specific, moving away from the central layers. This suggests that the laminar processing scheme for numerosity processing in the parietal cortex is similar to primary visual cortex, providing support for the canonical cortical microcircuit hypothesis beyond primary visual cortex.