CHEMOPROPHYLACTIC ACTIVITY OF IMIDOCARB, DIMINAZENE AND OXYTETRACYCLINE AGAINST BABESIA-BOVIS AND B-BIGEMINA
CHEMOPROPHYLACTIC ACTIVITY OF IMIDOCARB, DIMINAZENE AND OXYTETRACYCLINE AGAINST BABESIA-BOVIS AND B-BIGEMINA
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DOI：
10.1016/0304-4017(86)90151-2
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发表时间：
1986-06-01
影响因子：
2.6
通讯作者：
JOHNSON, LW
中科院分区：
文献类型：
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作者：
KUTTLER, KL;JOHNSON, LW
在治疗后的不同时间间隔内，分别给切除脾的小牛施用咪唑蟹、迪咪那烯和土霉素，以评估预防效果。在治疗后54天，迪米纳烯对双型双歧杆菌的攻击没有剩余活性。当暴露于双头双歧杆菌前2天给予土霉素时，可能导致潜伏期增加。吡虫威对双芽双歧杆菌和牛双歧杆菌均有显著的预防作用。用吡虫威1或2 mg kg-1治疗，治疗当日、治疗后7天，每14天暴露一次巴贝虫，共91天，延迟双母b型感染49天，延迟牛b型感染42天。吡虫威剂量为4或5 mg kg-1，随后再暴露类似的巴贝虫，可将未感染的牛b延缓68天，将双头b延缓81-103天，在某些情况下还可预防感染。在吡咪威治疗后，由于双胎b型或牛b型感染的延迟发病伴以明显较轻的临床反应。犊牛对初始刺激没有反应，在处理后196天对稳定刺激完全敏感。在吡虫威治疗和暴露后，小牛对b型牛有轻微的临床反应，但对196天的挑战暴露没有表现出任何反应迹象。在吡虫威治疗和接触后，犊牛对双芽双头虫出现轻度临床反应，在某些情况下，在初始治疗后196天出现第二次轻度反应。
Splenectomized calves treated with imidocrab, diminazene, and oxytetracycline were exposed to Babesia bigemina and B. bovis stabilates at various time intervals following treatment to evaluate prophylactic efficacy. Diminazene showed no resdual activity against a B. bigemina challenge given 54 days after treatment. Oxytetracycline appeared responsible for an increased incubation time when given 2 days prior to B. bigemina exposure. Imidocarb showed marked prophylactic efficacy against both B. bigemina and B. bovis. Treatment with 1 or 2 mg kg-1 imidocarb, followed by Babesia exposure on the day of treatment, 7 days after treatment, then every 14 days for 91 days, delayed patent B. bigemina infections for 49 days and patent B. bovis infections for 42 days. Imidocarb at 4 or 5 mg kg-1, followed by similar Babesia exposures, delayed patent B. bovis infections for 68 days, and delayed B. bigemina for 81-103 days, and in some instances prevented infections. The delayed onset of infection due to either B. bigemina or B. bovis, following imidocarb treatment was accompanied by a significantly milder clinical response. Calves not responding to the primary challenge were fully susceptible to stabilate challenge 196 days after treatement. Calves experiencing a mild clinical response to B. bovis following imidocarb treatment and exposure failed to show any signs of response to a 196-day challenge exposure. Calves experiencing a mild clinical response to B. bigemina following imidocarb treatment and exposure did, in some instances, show a second mild response when challenged 196 days after initial treatment.