MR-guided focused ultrasound: a potentially disruptive technology.
MR-guided focused ultrasound: a potentially disruptive technology.
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DOI：
10.1016/j.jacr.2009.01.004
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发表时间：
2009-07-01
期刊：
影响因子：
--
通讯作者：
Bradley, William G Jr
中科院分区：
文献类型：
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作者：
Bradley, William G Jr
颠覆性技术是一种科技创新，它颠覆了市场上现有的主导技术。磁共振（MR）引导的聚焦超声（MRgFUS）是一种基于实时磁共振解剖学引导、磁共振测温以及高强度聚焦超声相结合的非侵入性操作。在磁共振引导下，数百个换能器元件在一个点上聚焦，导致加热和凝固性坏死。在焦点之外，没有明显的加热。对于体内的操作无需破皮，对于脑部的操作无需进行开颅手术。这种无创性使得MRgFUS相较于手术具有如此大的颠覆性。目前，MRgFUS已用于子宫肌瘤、乳腺肿瘤、疼痛性骨转移瘤和肝脏肿瘤的消融。在脑部，它已用于胶质母细胞瘤的消融以及功能性神经外科手术。模型和动物研究表明其未来可应用于前列腺癌和急性中风治疗。
A disruptive technology is a technological innovation that overturns the existing dominant technologies in a market. Magnetic resonance (MR)-guided focused ultrasound (MRgFUS) is a noninvasive procedure based on the combination of real-time MR anatomic guidance, MR thermometry, and high-intensity focused ultrasound. Several hundred transducer elements become convergent at a point under MR guidance, leading to heating and coagulation necrosis. Outside the focal point, there is no significant heating. There is no need to break the skin for procedures in the body or to perform a craniotomy for procedures in the brain. This lack of invasiveness is what makes MRgFUS so disruptive compared with surgery. At present, MRgFUS has been used for the ablation of uterine fibroids, breast tumors, painful bony metastases, and liver tumors. In the brain, it has been used for the ablation of glioblastomas and for functional neurosurgery. Phantom and animal studies suggest future applications for prostate cancer and acute stroke treatment.