Photoswitchable single-walled carbon nanotubes for super-resolution microscopy in the near-infrared
Photoswitchable single-walled carbon nanotubes for super-resolution microscopy in the near-infrared
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DOI：
10.1126/sciadv.aax1166
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发表时间：
2019-09-01
期刊：
影响因子：
13.6
通讯作者：
Cognet, Laurent
中科院分区：
文献类型：
--
作者：
Godin, Antoine G.;Setaro, Antonio;Cognet, Laurent
单分子光开关发射器的设计是单分子定位显微镜出现的第一个里程碑，在光学成像领域建立了一个新的范例。已经开发了几种可光开关的发射器，但是它们都在可见光或远红外范围内发出荧光，缺少生物组织最透明的理想的近红外窗口。此外，对于基本光学分子开关或信息存储元件来说，在近红外中的各个发射器的光控制将是高度期望的，因为大多数通信数据传输协议是在该光谱范围内建立的。在这里，我们介绍了一种类型的混合纳米材料，由单壁碳纳米管共价官能化的光开关分子，用于控制在近红外（超过1 μ m）的单纳米管的本征发光。通过光开关的控制，我们证明了衍射极限显微镜无法分辨的纳米管的超局域化成像。
The design of single-molecule photoswitchable emitters was the first milestone toward the advent of single-molecule localization microscopy, setting a new paradigm in the field of optical imaging. Several photoswitchable emitters have been developed, but they all fluoresce in the visible or far-red ranges, missing the desirable near-infrared window where biological tissues are most transparent. Moreover, photocontrol of individual emitters in the near-infrared would be highly desirable for elementary optical molecular switches or information storage elements since most communication data transfer protocols are established in this spectral range. Here, we introduce a type of hybrid nanomaterials consisting of single-wall carbon nanotubes covalently functionalized with photoswitching molecules that are used to control the intrinsic luminescence of the single nanotubes in the near-infrared (beyond 1 mu m). Through the control of photoswitching, we demonstrate super-localization imaging of nanotubes unresolved by diffraction-limited microscopy.