Anticoagulant surface of 316 L stainless steel modified by surface-initiated atom transfer radical polymerization.
Anticoagulant surface of 316 L stainless steel modified by surface-initiated atom transfer radical polymerization.
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DOI：
10.1021/am200215x
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发表时间：
2011-05
影响因子：
9.5
通讯作者：
W. Guo;Jian Zhu;Zhenping Cheng;Zhengbiao Zhang;Xiu-lin Zhu
中科院分区：
文献类型：
--
作者：
W. Guo;Jian Zhu;Zhenping Cheng;Zhengbiao Zhang;Xiu-lin Zhu
采用空气等离子体对抛光后的316 L不锈钢表面进行处理，以提高其表面的亲水性，然后与2-（4-氯磺酰基苯基）乙基三甲氧基硅烷反应，引入原子转移自由基聚合（ATRP）引发剂。在此基础上，进行了聚乙二醇甲基丙烯酸酯（PEGMA）的表面引发原子转移自由基聚合。通过水接触角测量、X射线光电子能谱和原子力显微镜监测接枝过程。聚合物厚度作为不同聚合时间的函数，其特征在于使用阶梯轮廓仪。研究了PEGMA改性SS表面的抗凝血性能。结果表明，PEGMA接枝到SS表面后，对酸性柠檬酸盐葡萄糖（ACD）血液的抗凝作用增强。
Polished 316 L stainless steel (SS) was first treated with air plasma to enhance surface hydrophilicity and was subsequently allowed to react with 2-(4-chlorosulfonylphenyl)ethyltrimethoxysilane to introduce an atom transfer radical polymerization (ATRP) initiator. Accordingly, the surface-initiated atom transfer radical polymerization of polyethylene glycol methacrylate (PEGMA) was carried out on the surface of the modified SS. The grafting progress was monitored by water contact angle measurements, X-ray photoelectron spectroscopy and atomic force microscopy. The polymer thickness as a function different polymerization times was characterized using a step profiler. The anticoagulative properties of the PEGMA modified SS surface were investigated. The results showed enhanced anticoagulative to acid-citrate-dextrose (ACD) blood after grafting PEGMA on the SS surface.