Structure of anchoring villi and the trophoblastic shell in the human, baboon and macaque placenta
Structure of anchoring villi and the trophoblastic shell in the human, baboon and macaque placenta
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DOI：
10.1053/plac.2001.0626
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发表时间：
2001-04-01
期刊：
影响因子：
3.8
通讯作者：
Jones, CJP
中科院分区：
文献类型：
--
作者：
Enders, AC;Blankenship, TN;Jones, CJP
用光镜和电子显微镜观察了猕猴、恒河猴和人类妊娠早期胎盘的锚定绒毛。狒狒和猕猴的锚定绒毛类似于人类的锚定绒毛，其细胞柱呈摩尔状细长，细胞滋养层细胞之间的细胞外基质较多。这些物种也有更厚和更均匀的滋养层外壳。与绒毛间充质相邻的细胞滋养层细胞的发生区域在所有三种动物中都是相似的，核心与该区域相邻的方面是由一个加厚的基底板排列的。同样，在这三个物种中，迁移的细胞滋养层细胞形成细胞外基质，但在非人类灵长类动物中，锚定绒毛和贝壳NLE的基质丰富区域更为广泛。细胞外基质，特别是类似纤维蛋白的物质，可能有助于加强绒毛，特别是非人灵长类动物的细长绒毛。也可能阻止母体细胞迁移到滋养层外壳，形成这种基质的狒狒和猕猴细胞滋养层细胞往往通过缝隙和桥粒连接并排列在一起，而人类中那些被阻止到达正常蜕膜的细胞形成丰富的细胞外基质，但没有缝隙连接。恒河猴、恒河猴细胞滋养层细胞是否不能广泛侵袭子宫内膜，与细胞外基质增多有关。它们离间充质细胞的距离更远，或者它们的细胞间联系尚不清楚。对猕猴或狒狒的分离绒毛的研究，就像在人类中广泛开展的那样，可能有助于确定细胞滋养层细胞是否是天生的。不同或正在回应(C)2001哈考特出版有限公司。
Anchoring villi of first trimester placentae of the macaque, baboon and human were examined by light and electron microscopy. The anchoring villi of the baboon and macaque are similar in having mole elongated cell columns than those of the human and in having more extracellular matrix between cytotrophoblast cells. These species also have a thicker and more uniform trophoblastic shell. The generative region of cytotrophoblast cells adjacent to the villous mesenchyme is similar in all three species, with the aspect of the core abutting this area being lined bq a thickened basal lamina. Similarly, migratory cytotrophoblast cells form extracellular matrix in all three species, but matrix-rich regions of the anchoring villi and shell nle more extensive in the non-human primates. The extracellular matrix and especially the material resembling fibrillin may serve to strengthen the villi, particularly the elongated villi of the non-human primate. and also may prevent maternal cells migrating into the trophoblastic shell, The baboon and macaque cytotrophoblast cells that form this matrix tend to he linked by gap and desmosomal junctions and are in contiguous arrays, whereas those in the human that are blocked from reaching normal decidua form abundant extracellular matrix but have no gap junctions. Whether the lack of extensive invasion of the endometrium by baboon and macaque cytotrophoblast cells is related to the increased amount of extracellular matrix. their greater distance from the mesenchymal cole, or their intercellular linkages is not known. The investigation of isolated villi from the macaque or baboon, as has been extensively carried out in the human, might help to determine whether the cytotrophoblast cells are intrinsically. different or are responding (C) 2001 Harcourt Publishers Ltd.