ARE THERE EFFECTIVE RESISTANCE MANAGEMENT STRATEGIES FOR VECTORS OF HUMAN-DISEASE
ARE THERE EFFECTIVE RESISTANCE MANAGEMENT STRATEGIES FOR VECTORS OF HUMAN-DISEASE
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DOI：
10.1111/j.1095-8312.1993.tb00873.x
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发表时间：
1993-01-01
影响因子：
1.9
通讯作者：
KASIM, SH
中科院分区：
文献类型：
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作者：
CURTIS, CF;HILL, N;KASIM, SH
轮的盘尾丝虫病控制方案在西非使用的杀虫剂进行审查，这种轮换的动机被证明不仅是管理temephos抗性theSimulium载体，但也限制了什么样的化合物可用于在特定的季节。一个计算机模型表明，如果没有这些季节性的限制，预先计划的杀虫剂轮换不太可能是一个优势，相比之下，迅速转换化合物的检测建立的阻力和切换回原来的化合物，如果发现阻力的回归给这样做的机会。后一系列事件很难被称为抗药性管理的“战略”，但却是任何管理良好的害虫控制方案所期望的。使用杀虫剂混合物原则上不同于使用轮换，并取决于这样一种想法，即如果从一开始就使用混合物，当对混合物的两种成分的抗药性可能都很罕见时，这种双重抗性组合是如此罕见，以至于与那些完全避免暴露的昆虫相比，其数量将相形见绌。一种混合物能否成功使用，取决于每一种成分能否杀死很高比例的接触过的昆虫，而这些昆虫在遗传上对这种混合物敏感。
The rotation of insecticides used by the Onchocerciasis Control Programme in West Africa is reviewed and the motives for this rotation are shown to be not only management of temephos resistance in theSimuliumvectors but also constraints on what compounds are usable at particular seasons. A computer model indicates that without these seasonal constraints there is unlikely to be an advantage in a pre-planned rotation of insecticides, as compared with the prompt switching of compounds as dictated by detection of build up of resistance and switching back to the original compound if the regression of resistance is found to give the opportunity to do so. The latter sequence of events can hardly be called a ‘strategy’ for resistance management, but is what any well-managed pest control programme would be expected to do.The use of an insecticide mixture is different in principle from the use of rotation and depends on the idea that if the mixture is used from the outset, when resistance to both components of the mixture is likely to be rare, the double resistance combination would be so rare as to be dwarfed in numbers by those insects which avoid exposure altogether. The prospects for successful use of a mixture depend on each component killing a very high percentage of the exposed insects which are genetically susceptible to it. Whether this condition is met could be tested, for example, in the case of exposure of mosquitoes to insecticide-treated bednets.