A Novel Low-Cost Approach to Estimate the Incidence of Japanese Encephalitis in the Catchment Area of Three Hospitals in Bangladesh
A Novel Low-Cost Approach to Estimate the Incidence of Japanese Encephalitis in the Catchment Area of Three Hospitals in Bangladesh
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DOI：
10.4269/ajtmh.2011.10-0706
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发表时间：
2011-08-01
影响因子：
3.3
通讯作者：
Luby, Stephen P.
中科院分区：
文献类型：
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作者：
Paul, Repon C.;Rahman, Mahmudur;Luby, Stephen P.
2007年10月在孟加拉国的三所医学院医院启动了急性脑膜脑炎综合征监测，以确定日本脑炎病例。我们估计人口为基础的发病率，在三家医院的集水区的乙脑，调整基于医院的乙脑的粗发病率的比例集水区脑膜脑炎病例谁被送入监测医院。我们尝试了一种新的方法，通过社区居民之间的社交网络来识别医院集水区的脑膜脑炎病例，而不是传统的挨家挨户的调查，这种调查对于低频率的疾病来说是昂贵的。估计的乙脑发病率在拉杰沙希为2.7/10万人（95%置信区间[CI] = 1.8-4.9），库尔纳为1.4（95% CI = 0.9-4.1），吉大港为0.6（95% CI = 0.4-0.9）。孟加拉国应考虑开展一个试点项目，在高发病率地区引进乙脑疫苗。
Acute meningoencephalitis syndrome surveillance was initiated in three medical college hospitals in Bangladesh in October 2007 to identify Japanese encephalitis (JE) cases. We estimated the population-based incidence of JE in the three hospitals' catchment areas by adjusting the hospital-based crude incidence of JE by the proportion of catchment area meningoencephalitis cases who were admitted to surveillance hospitals. Instead of a traditional house-to-house survey, which is expensive for a disease with low frequency, we attempted a novel approach to identify meningoencephalitis cases in the hospital catchment area through social networks among the community residents. The estimated JE incidence was 2.7/100,000 population in Rajshahi (95% confidence interval [CI] = 1.8-4.9), 1.4 in Khulna (95% Cl = 0.9-4.1), and 0.6 in Chittagong (95% CI = 0.4-0.9). Bangladesh should consider a pilot project to introduce JE vaccine in high-incidence areas.