CHROMOSOMAL LOCALIZATION OF THE HUMAN RETINOID-X RECEPTORS
CHROMOSOMAL LOCALIZATION OF THE HUMAN RETINOID-X RECEPTORS
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DOI：
10.1006/geno.1994.1193
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发表时间：
1994-04-01
期刊：
影响因子：
4.4
通讯作者：
EVANS, RM
中科院分区：
文献类型：
--
作者：
ALMASAN, A;MANGELSDORF, DJ;EVANS, RM
最近描述的类视黄醇 X 受体 (RXR) 对新型类视黄醇 9-顺式视黄酸有反应，也可作为维生素 D、甲状腺激素和视黄酸受体（分别为 VDR、TR 和 RAR）的异二聚体伴侣。在这项工作中，我们报告了人类 RXR 基因在细胞遗传学带内以及人类染色体上粘粒 DNA 标记的标准参考图谱内的高分辨率定位。我们使用荧光原位杂交，通过 RXR 粘粒和参考标记的成对杂交，确定了人类 RXR 基因的位置。我们将 (i) RXR α (RXRA) 定位于 9 号染色体带 q34.3； (ii) RXR β (RXRB) 至 6 号染色体条带 21.3； (iii) RXR gamma (RXRG) 至染色体 1 带 q22-q23。迄今为止，已鉴定出六种类视黄醇反应性转录因子，其中除了三个 RXR 外，还包括三个视黄酸受体。有趣的是，人类和小鼠的这些受体中的每一个都是由位于不同染色体位点和不同染色体上的基因编码的。 RXR 基因与已知与遗传性疾病相关的位点的接近表明它们的位置可能有助于建立 RXR 与某些人类疾病之间的联系。 (C) 1994 学术出版社
The recently described retinoid X receptors (RXRs) respond to the novel retinoid 9-cis-retinoic acid and also serve as heterodimeric partners for the vitamin D, thyroid hormone, and retinoic acid receptors (VDR, TR, and RAR, respectively). In this work, we report high-resolution localization of the human RXR genes within cytogenetic bands and also within a standard reference map of cosmid DNA markers on human chromosomes. We have determined the location of the human RXR genes by pairwise hybridization of the RXR cosmids and reference markers, using fluorescence in situ hybridization. We localized (i) RXR alpha (RXRA) to chromosome 9 band q34.3; (ii) RXR beta (RXRB) to chromosome 6 band 21.3; and (iii) RXR gamma (RXRG) to chromosome 1 band q22-q23. Six retinoid-responsive transcription factors have been identified so far, including three retinoic acid receptors in addition to the three RXRs. Interestingly, each of these receptors in human and mouse is encoded by genes located at distinct chromosomal loci and on separate chromosomes. The proximity of RXR genes to loci known to be associated with genetic disorders suggests that their location may be useful in establishing a link between RXRs and certain human diseases. (C) 1994 Academic Press,Inc.