Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology
Glucocorticoid exposure in late gestation in the rat permanently programs gender-specific differences in adult cardiovascular and metabolic physiology
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DOI：
10.1152/ajpendo.00137.2004
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发表时间：
2004-11-01
影响因子：
5.1
通讯作者：
Holmes, MC
中科院分区：
文献类型：
--
作者：
O'Regan, D;Kenyon, CJ;Holmes, MC
子宫内糖皮质激素过量可能是低出生体重与随后常见心血管和代谢病变发展之间相关性的基础。以前，我们已经表明，产前地塞米松（DEX）暴露在大鼠降低出生体重和程序的下丘脑-垂体轴和空腹和餐后高血糖症的成年男性和女性的高血压。本研究旨在确定1）产前DEX程序化后代是否存在性别差异，以及2）肾素-血管紧张素系统（RAS）是否在高血压程序化中发挥作用。在子宫内暴露于DEX的大鼠（从胚胎第14-21天起100mug.kg）出生体重较低（降低12%，P
Glucocorticoid overexposure in utero may underlie the association between low birth weight and subsequent development of common cardiovascular and metabolic pathologies. Previously, we have shown that prenatal dexamethasone (DEX) exposure in rat reduces birth weight and programs the hypothalamic-pituitary axis and fasting and postprandial hyperglycemia in adult males and hypertension in adult males and females. This study aimed to determine 1) whether there were gender differences in prenatal DEX-programmed offspring, and 2) whether the renin-angiotensin system (RAS) plays a role in the programming of hypertension. Rats exposed to DEX in utero (100 mug.kg(-1).day(-1) from embryonic days 14-21) were of lower birth weight (by 12%, P