Chemical composition, antitumor activity, and toxicity of essential oil from the leaves of Lippia microphylla
Chemical composition, antitumor activity, and toxicity of essential oil from the leaves of Lippia microphylla
复制标题
小叶唇瓣精油的化学成分、抗肿瘤活性及毒性
DOI：
10.1515/znc-2014-4138
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
M. Sobral
中科院分区：
文献类型：
--
作者：
A. L. Xavier;J. C. L. Pita;M. Brito;D. R. Meireles;J. Tavares;M. S. Silva;J. Maia;E. Andrade;M. Diniz;T. Silva;H. Pessôa;M. Sobral
Abstract The chemical composition, antitumor activity and toxicity of the essential oil from Lippia microphylla leaves (OEL) were investigated. The major constituents were thymol (46.5%), carvacrol (31.7%), p-cymene (9%), and γ-terpinene (2.9%). To evaluate the toxicity of OEL in non-tumor cells, the hemolytic assay with Swiss mice erythrocytes was performed. The concentration producing 50% hemolysis (HC50) was 300 μg/mL. Sarcoma 180 tumor growth was inhibited in vivo 38% at 50 mg/kg, and 60% at 100 mg/kg, whereas 5-FU at 50 mg/kg caused 86% inhibition. OEL displays moderate gastrointestinal and hematological toxicity along with causing some alteration in liver function and morphology. However, the changes were considered reversible and negligible in comparison to the effects of several anticancer drugs. In summary, OEL displays in vivo antitumor activity and a moderate toxicity, which suggests further pharmacological study.
