A case of hook effect in the serum free light chain assay using the Olympus AU400e
A case of hook effect in the serum free light chain assay using the Olympus AU400e
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DOI：
10.1016/j.clinbiochem.2008.10.005
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发表时间：
2009-01-01
影响因子：
2.8
通讯作者：
Hammett-Stabler, Catherine A.
中科院分区：
文献类型：
--
作者：
McCudden, Christopher R.;Voorhees, Peter M.;Hammett-Stabler, Catherine A.
我们描述的情况下，一个女人与IgG λ单克隆丙种球蛋白病有一个无法检测到的血清游离λ轻链由于抗原过量。该患者有3年多发性骨髓瘤病史，最初表现为血清游离λ轻链升高。血清游离λ轻链浓度在几个月的过程中增加到>4000 mg/L（参考区间5.7-26.3 mg/L），然后突然下降到>4000 mg/L（参考区间5.7-26.3 mg/L）。
We describe a case where a woman with an IgG lambda monoclonal gammopathy had an undetectable serum free lambda light chain due to antigen excess. The patient had a three year history of multiple myeloma and initially presented with an elevated serum free lambda light chain. The serum free lambda light chain concentration increased over the course of several months to >4000 mg/L (reference interval 5.7-26.3 mg/L) and then suddenly dropped to