Nickel-induced alterations to chromatin structure and function.
Nickel-induced alterations to chromatin structure and function.
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DOI：
10.1016/j.taap.2022.116317
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发表时间：
2022-11
影响因子：
3.8
通讯作者：
A. Gaspar;Suresh Cuddapah
中科院分区：
文献类型：
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作者：
A. Gaspar;Suresh Cuddapah
由于自然和人为活动，镍 (Ni) 是一种重金属，在大气中普遍存在。镍是一种致癌物质，与人类肺癌和鼻癌的发展有关。此外，镍暴露与人类许多慢性肺部疾病有关，包括哮喘、慢性支气管炎、肺气肿、肺纤维化、肺水肿和慢性阻塞性肺病(COPD)。虽然镍化合物是弱诱变剂，但许多研究已经证明镍具有改变表观基因组的潜力，表明表观基因组失调是其致病性的重要根本原因。在真核细胞核中，DNA 通过组装高阶染色质结构而组织在三维 (3D) 空间中。这样的组织对于转录和其他生物活动至关重要。越来越多的证据表明，通过对各种细胞调节过程产生负面影响，镍可能会影响染色质组织。在这篇综述中，我们讨论了镍在改变染色质结构中的作用，这可能在镍的致病性中发挥着重要作用。
Nickel (Ni), a heavy metal is prevalent in the atmosphere due to both natural and anthropogenic activities. Ni is a carcinogen implicated in the development of lung and nasal cancers in humans. Furthermore, Ni exposure is associated with a number of chronic lung diseases in humans including asthma, chronic bronchitis, emphysema, pulmonary fibrosis, pulmonary edema and chronic obstructive pulmonary disease (COPD). While Ni compounds are weak mutagens, a number of studies have demonstrated the potential of Ni to alter the epigenome, suggesting epigenomic dysregulation as an important underlying cause for its pathogenicity. In the eukaryotic nucleus, the DNA is organized in a three-dimensional (3D) space through assembly of higher order chromatin structures. Such an organization is critically important for transcription and other biological activities. Accumulating evidence suggests that by negatively affecting various cellular regulatory processes, Ni could potentially affect chromatin organization. In this review, we discuss the role of Ni in altering the chromatin architecture, which potentially plays a major role in Ni pathogenicity.