Is the short-latency dopamine response too short to signal reward error?
Is the short-latency dopamine response too short to signal reward error?
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DOI：
10.1016/s0166-2236(98)01373-3
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发表时间：
1999-04-01
影响因子：
15.9
通讯作者：
Gurney, K
中科院分区：
文献类型：
--
作者：
Redgrave, P;Prescott, TJ;Gurney, K
在行为上有意义的意想不到的刺激能够在中脑多巴胺能神经元中诱发短潜伏期、短持续时间的放电爆发。对描述这种反应的实验数据的一种有影响力的解释表明：多巴胺能神经元在强化学习中起着关键作用，因为它们在预测未来奖励时发出错误信号。在这篇文章中，我们提出了这种“短潜伏期多巴胺反应”在联想学习机制中的不同功能作用。我们认为，最初的多巴胺能神经元放电可能代表着将注意力和行为选择切换到意想不到的行为重要刺激的过程中的一个重要组成部分。这种转换反应可能是联想学习的关键前提，也可能是由儿茶酚胺介导的一般短潜伏期反应的一部分，并为有机体对具有生物学意义的事件的适当反应做好准备。
Unexpected stimuli that are behaviourally significant have the capacity to elicit a short-latency, short-duration burst of firing in mesencephalic dopaminergic neurones. An influential interpretation of the experimental data that characterize this response proposes that: dopaminergic neurones have a crucial role in reinforcement learning because they signal error in the prediction of future reward. In this article we propose a different functional role for this 'short-latency dopamine response' in the mechanisms that underlie associative learning. We suggest that the initial burst of dopaminergic-neurone firing could represent an essential component in the process of switching attentional and behavioural selections to unexpected, behaviourally important stimuli. This switching response could be a crucial prerequisite for associative learning and might be part of a general short-latency response that is mediated by catecholamines and prepares the organism for an appropriate reaction to biologically significant events.