Small Signaling Molecules and CO-Releasing Molecules (CORMs) for the Modulation of the Cellular Redox Metabolism
Small Signaling Molecules and CO-Releasing Molecules (CORMs) for the Modulation of the Cellular Redox Metabolism
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DOI：
10.1007/978-3-319-30705-3_13
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
P. Simpson;U. Schatzschneider
中科院分区：
文献类型：
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作者：
P. Simpson;U. Schatzschneider
一氧化碳（CO）与一氧化氮（NO）和硫化氢（H2S）一起，属于一类内源性小信号分子，在过去的二十年中，由于其迷人的特性和潜在的治疗应用，在生物医学界得到了越来越多的关注。本文比较了这三种信号分子的化学性质以及它们的内源性酶生产，然后批判性地回顾了一氧化碳的分子传递系统，即所谓的co释放分子（CORMs）。不同的触发机制，以启动一氧化碳从分子载体系统的解放被讨论和评估其在生物学研究中的效用。
Together with nitric oxide (NO) and hydrogen sulfide (H2S), carbon monoxide (CO) belongs to a class of small endogenously produced signaling molecules which has gained steadily increasing attention in the biomedical community over the last two decades due to their fascinating properties and potential therapeutic applications in human medicine. The present review compares the chemical properties of these three signaling molecules as well as their endogenous enzymatic production and then critically reviews molecular delivery systems for carbon monoxide, the so-called CO-releasing molecules (CORMs). Different trigger mechanisms to initiate the liberation of carbon monoxide from molecular carrier systems are discussed and assessed for their utility in biological studies.