Nanoparticle enhanced optical imaging and phototherapy of cancer.
Nanoparticle enhanced optical imaging and phototherapy of cancer.
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DOI：
10.1166/jbn.2014.1988
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发表时间：
2014-09
影响因子：
2.9
通讯作者：
Allison M. Pekkanen;Matthew R. DeWitt;M. Rylander
中科院分区：
文献类型：
--
作者：
Allison M. Pekkanen;Matthew R. DeWitt;M. Rylander
纳米粒子研究在许多领域取得了进展，包括癌症的成像和治疗。具体而言，纳米技术已被研究其作为一种工具，通过被动和主动肿瘤靶向，以潜在的更安全的浓度提供经过充分测试的药物，同时还提供了二次治疗或成像对比的手段。特别地，由于利用光能的进步，近年来结合基于纳米颗粒的成像和治疗使用光已经越来越受欢迎。在这篇综述中，我们将首先讨论可用于癌症光学成像的纳米颗粒平台，例如量子点荧光生成和等离子体纳米颗粒表面增强拉曼散射。然后，我们分析纳米粒子疗法，包括光热疗法，光动力疗法，光声疗法和它们在利用光治疗癌症方面的差异。特别是对于光热疗法，我们已经汇总了金纳米颗粒治疗方案中关键变量的数据，例如暴露能量和纳米颗粒浓度，并希望强调在不同实验条件和能源下变量报告标准化的必要性。我们还讨论了使用纳米颗粒将化疗药物共同递送到肿瘤的潜力，以及如何利用光进行多功能癌症治疗。最后，目前在体外测试这些疗法的方法进行了讨论，以及通过3D组织幻影的临床可翻译性提高的潜力。这篇综述的重点是首次全面比较各种基于光的纳米粒子相互作用，从基础科学到临床方面和未来方向，产生新的治疗和成像工具。
Nanoparticle research has seen advances in many fields, including the imaging and treatment of cancer. Specifically, nanotechnology has been investigated for its potential to be used as a tool to deliver well-tested drugs in potentially safer concentrations through both passive and active tumor targeting, while additionally providing means for a secondary therapy or imaging contrast. In particular, the use of light in conjunction with nanoparticle-based imaging and therapies has grown in popularity in recent years due to advances in utilizing light energy. In this review, we will first discuss nanoparticle platforms that can be used for optical imaging of cancer, such as fluorescence generation with quantum dots and surface-enhanced Raman scattering with plasmonic nanoparticles. We then analyze nanoparticle therapies, including photothermal therapy, photodynamic therapies, and photoacoustic therapy and their differences in exploiting light for cancer treatment. For photothermal therapies in particular, we have aggregated data on key variables in gold nanoparticle treatment protocols, such as exposure energy and nanoparticle concentration, and hope to highlight the need for normalization of variable reporting across varying experimental conditions and energy sources. We additionally discuss the potential to co-deliver chemotherapeutic drugs to the tumor using nanoparticles and how light can be harnessed for multifunctional approaches to cancer therapy. Finally, current in vitro methods of testing these therapies is discussed as well as the potential to improve on clinical translatability through 3D tissue phantoms. This review is focused on presenting, for the first time, a comprehensive comparison on a wide variety of photo based nanoparticle interactions leading to novel treatments and imaging tools from a basic science to clinical aspects and future directions.