Amino acid-based surfactants: New antimicrobial agents
Amino acid-based surfactants: New antimicrobial agents
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DOI：
10.1016/j.cis.2015.11.007
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发表时间：
2016-02-01
影响因子：
15.6
通讯作者：
Perez, L.
中科院分区：
文献类型：
--
作者：
Pinazo, A.;Manresa, M. A.;Perez, L.
耐药细菌的迅速增加使得开发新的抗菌药物成为必要。合成的氨基酸基表面活性剂是传统抗菌化合物的一种有希望的替代品，因为它们可以从可再生的原材料中制备出来。在这篇综述中，我们讨论了提高氨基酸基表面活性剂抗菌活性的结构特征。修改了极性头部含有不同氨基酸并显示出抗细菌活性的单链、双链和双子表面活性剂。还介绍了该化合物的合成和基本物化性质。(C)2015爱思唯尔B.V.保留所有权利。
The rapid increase of drug resistant bacteria makes necessary the development of new antimicrobial agents. Synthetic amino acid-based surfactants constitute a promising alternative to conventional antimicrobial compounds given that they can be prepared from renewable raw materials. In this review, we discuss the structural features that promote antimicrobial activity of amino acid-based surfactants. Monocatenary, dicatenary and gemini surfactants that contain different amino acids on the polar head and show activity against bacteria are revised. The synthesis and basic physico-chemical properties have also been included. (C) 2015 Elsevier B.V. All rights reserved.