Overexpression of VCC-1 gene in human hepatocellular carcinoma cells promotes cell proliferation and invasion
Overexpression of VCC-1 gene in human hepatocellular carcinoma cells promotes cell proliferation and invasion
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DOI：
10.1093/abbs/gmp051
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发表时间：
2009-08-01
影响因子：
3.7
通讯作者：
Li, Ming
中科院分区：
文献类型：
--
作者：
Mu, Xia;Chen, Yao;Li, Ming
血管内皮生长因子相关趋化因子1 （VCC-1）是一种新的趋化因子，被认为与癌症发生有关。vc -1在肝细胞癌（HCC）细胞中表达，但其功能尚不清楚。为了研究vc -1对肝癌细胞的分子作用，我们用重组质粒pcDNA3.1/ vc -1稳定转染肝癌细胞系SMMC7721。我们的数据表明，与空载体对照细胞和亲本细胞相比，SMMC7721细胞中VCC-1的过表达显著增强了细胞增殖、侵袭能力和肿瘤生长。这些结果强烈提示，VCC-1在SMMC7721侵袭和肿瘤生长中发挥重要作用，并提示VCC-1可能作为抗hcc治疗的潜在生物标志物。
Vascular endothelial growth factor-correlated chemokine 1 (VCC-1), a novel chemokine, is hypothesized to be associated with carcinogenesis. VCC-1 is expressed in hepatocellular carcinoma (HCC) cells, but its function remains unknown. To investigate the molecular effects of VCC-1 on HCC cells, the HCC cell line SMMC7721 was stably transfected with the recombinant plasmid pcDNA3.1/VCC-1. Our data demonstrated that overexpression of VCC-1 in SMMC7721 cells significantly enhanced the cellular proliferation, invasive ability, and tumor growth, when compared with both empty vector control cells and parental cells. These results strongly suggest that VCC-1 plays an important role in SMMC7721 invasion and tumor growth, and indicate that VCC-1 may serve as a potential biomarker for anti-HCC therapies.